• Adachi, T., Wang, J. & Wang, X.L. (2000) Age-related change of plasma extracellular-superoxide dismutase.Clin Chim Acta, 290, 169-178.
  • Adamo KB, Sigal RJ, Williams K, Kenny G, Prud’homme D, and Tesson F. Influence of Prol2Ala peroxisome proliferator-activated receptor gamma2 polymorphism on glucose response to exercise training in type 2 diabetes. Diabetologia 48: 1503-1509, 2005.
  • Afman L, Muller M. Nutrigenomics: from molecular nutntion to prevention of disease. J Am Diet Assoc 2006;1 06(4):569-76.
  • Agalliu, [,Langeberg, W.J., Lampe, J.W., 2006, Glutathione S-Transferase M1,T1, and P1 Polyrnorphisnıs and Prostate Cancer Risk inMiddle-Aged Men, The Prostate, 66, 146-56
  • Ainsworth BE, Haskell WL, Whitt MC, Irwin ML, Swartz AM, Strath SJ, O’Bnan WL, Bassett DR, Schmitz KH, Emplaincourt P0, Jacobs DR, and Leon AS. Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exerc 32 (Suppl 9): S498-S504, 2000.
  • Ak, A.A., Fa, A.M.. Larbi, E.B., 2005, “Frequency of methylenetetrahydrofolate reductase C677T polymorphism of patients with cardiovascular disease in Eastern Saudi Arabia, Saudi Med J, 26:12, 1886-8
  • Alexandne, A.-K., Warholm, M., et al. (2000) CYPİAİ and GSTMİ polymorphisms affect urinary 1 hydroxypyrene levels after PAH exposure Carcinogenesis 21(4): 669-676.
  • Allen, M. H., Wakelin, S. H., Holloway, D., Lisby, S., Baadsgaard, 0., Barker, J. N., and McFadden, J. P. (2000).Association of TNFA gene polymorphism at position -308 with susceptibility to irritant contact dermatitis.Immunogenetics 51, 20 1-205.
  • Almavi, W.Y., Tamim, H., Kreidy, R., 2006, “A Case Control Study on the Contribution of Factor V-Leiden, Prothrombin G20210A, and MTHFR C677T Mutations to the Genetic Susceptibility of Deep Venous Thrombosis”, J Thrombosis and Thrombolysis, 19:3, 189-96
  • Altshuler, D., Hirschhorn, J. N., Klannemark, M., Lindgren, C. M., VohI, M. C., Nemesh, J., Lane, C. R., Schaffner, S. F., Bolk, S., Brewer, C., et al. (2000). The common PPARgamma Prol2Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet 26, 76-80.
  • Altshuler, D., Hirschhorn, J.N., Kiannemark, M., 2000, “The common PPARy Prol2Ala polymorphism is associated with decreased risk of type 2 diabetes”, Nature Genet, 26, 76-80
  • ‘ Alvarez, V., Mata, l.F., Gonzalez, P., 2002, U Association between the TNF-a -308 G/A polymorphism and the onset age of Alzheimer disease”, Neuropsychiatric Genet, 114, 574-7.
  • American Academy of Family Physicians (AAFP). Summary of recommendations for clinical preventive services. Leawood (KS): American Academy of Family Physicians (AAFP); 2012 Oct. 19 p.
  • American Association of Clinical Endocrinologists (AACE). American Association of Clinical Endocrinologists medical guidelines for clinical practice for the management of diabetes mellitus. Microvascular complications. Endocr Pract 2007 May-Jun;13(Suppl 1):50-5.
  • ‘ American College of Obstetricians and Gynecologists (ACOG). Breast cancer screening. American College of Obstetricians and Gynecologists (ACOG); 2011 Aug. 11 p. (ACOG practice bulletin; no. 122).
  • American College of Obstetricians and Gynecologists (ACOG). Osteoporosis. Washington (DC): American College of Obstetricians and Gynecologists (ACOG); 2012 Sep. 17 p. (ACOG practice bulletin; no. 129).
  • American College of PreventNe Medicine (ACPM). Nawaz H, Katz DL. American College of Preventive Medicine Practice Policy statement. Weight management counseling of overweight adults. Am J Prey Med 2001.
  • ‘ American College of Sports Medicine, American Diabetes Association. Exercise and type 2 diabetes: American College of Sports Medicine and the American Diabetes Association: joint position statement. Med Sci Sports Exerc 2010 Dec;42(12):2282-303.
  • American Dietetic Association (ADA). Diabetes type I and 2 evidence-based nutrition practice guideline for adults. Chicago (IL): American Dietetic Association (ADA); 2008
  • American Institute for Cancer Research and World Cancer Research Fund. Food, Nutrition, Physical Activity and the Prevention of Cancer a Global Perspective. Nov 2007.
  • Amit, K., Kanjanksha, G., Shrimati, S., 2004, Combination of thrombophilia markers in acute myocardial infarction of the young”, Ind J Med Sci, 58:9, 381-8.
  • Anderer, G., M. Schrappe, et al. (2000). Polymorphisms within glutattıione S-transferase genes and initial response to glucocorticoids in childhood acute lymphoblastic leukemia. Pharmacogenetics 10(8): 715-26.
  • Andersen T, Backer OG, Stokholm K H, et al. Randomized trial of diet and gastroplasty compared with diet alone in morbid obesity. New England Journal of Medicine 1984;310(6):352-6.
  • Andersen, C.B., Chnstiansen, L., Tan, Q., 2004, “Possible Gene Dosage Effect of Glutathione-Stransferases on Atopic Asthma: Using Real-Time PCR for Quantification of GSTMI and GSTTI Gene Copy Numbers”, Hum Mut, 24,218-24.
  • Anderson, F.A., Frederick, A.S., 2003, “ Risk Factors for Venous Thromboembolism”, Circulation, 107, 9-16.
  • ‘Andreotti, F., Porto, L, Crea, F., and Maseri, A. <2002). Inflammatory gene polymorphisms and ischaemic heart disease: review of population association studies. Heart 87, 107-112. • Antony PM, Balling R, Vlassis N. From Systems Biology to Systems Biomedicine. Curr Opin Biotechnol. 2011. Epub 2011/11/29. • aput J, Evelo CT, Perozzi G, van Ommen B, Cotton R. Connecting the Human Vanome Project to nutrıgenomics. Genes Nutr. 2010;5(4):275-83. •Arai, H., Yamamoto, A., Matsuzawa, Y., 2005, “Polymorphisms in four genes related to triglyceride and HDL cholesterol levels in the general Japanese population in 2000”, J Atherosder Thromb,12, 240-250 •Aras, 0., Hanson, N. Q., Yang, F., and Tsai, M. V. (2000). Influence of 699C—>T and 1080C—>T polymorphisms of the cystathionine beta-synthase gene on plasma homocysteine levels. Ciin Genet 58,455-459.
  • Arkadianos I, Valdes AM, Mannos E, Florou A, Gill RD, Grimaldi KA. Improved weight management usinggenetic information to personalize a calorie controlled diet. Nutrition journal. 2007;6:29.
  • Artac M, Dalton ARH, Majeed A, Car J, Millett C. Effectiveness of a national cardiovascular disease risk assessment program (NHS Health Check): Results after one year. Preventive Medicine. 2013;57(2):129-34.
  • Ates, N.A., Tamer, L., Ates, C., 2005, “Glutathione S-Transferase Ml, Tl, P1 Genotypes and Risk for Development of Colorectal Cancer”, Bioclıem Genet, 43:3-4, 149-1 63.
  • Auffray C BR, Benson M, Bertero M, Byrne H, Cascante M, Colding-Jörgensen M, De Pauw E, Fabbri LM, Foulkes T, Goryanin I, Harrison D, Henney A, Hoeveler A, Iris F, Kyriakopoulou C, Klingmüller U, Kolch W, Lahesmaa R, Lemberger T, Lévi F, Lichtenberg H, Lotteau V, Mayer B, Mialhe A, Mulligan B, Rozman D, Siest G, Swinton J, Ueffing M. From Systems Biology to Systems Medicine, European Commission, DG Research, Directorate of Health. Brussels 14-15 June 2010. Workshop report. 2010.
  • Auffray C, Chen Z, Hood L. Systems medicine: the future of medical genomics and healthcare. Genome Med. 2009;1 (1):2.
  • Australian National Health and Medical Research Council (NHMRC). Clinical Practice Guidelines for the Management of Overweight and Obesity in Adults. Endorsed 18 September 2003. Commonwealth of Australia 2003.
  • Autrup, H. (2000). Genetic polymorphisms in human xenobiotica metabolizing enzymes as susceptibility factors in toxic response. Mutat Res 464(1): 65-76.
  • Aznar J, Mira y, yaya A, Corolla D, Ferrando F, Villa P, Estelles A., 2004, Factor V Leiden and prothrombin G20210A mutations in young adults with cıyptogenic ischemic stroke” , Thromb Haemost, 91(5):1031-4.
  • Baccini M, Bachmaier EM, Biggeri A, Boekschoten MV, Bouwman FG, Brennan L, et al. The NuGO proof of principle study package: a collaborative research effort of the European Nutrigenomics Organisation. Genes Nutr. 2008;3(3-4):147-51.
  • Bailey, L.B., Duhaney, R.L., Maneval, D.R., “Vitamin B12 status is inversely associated with plasma homocysteine in young women with C677T and/or A1298C MTHFR polymorphisms”, J Nutr, 132, 1872-78
  • Balding, J., Livingstone, W.J., Pittock, S.J., 2004, “The IL-6 G-174C polymorphism may be associated with ischaemic stroke in patients without a history of hypertension, Ir J Med Sci, 173:4, 200-3.
  • Balog, A., Gal, J., Gyulai, Z., 2004, “TNF- and heat shock protein 70-2 gene polymorphisms in a family with rheumatid arthritis”, Acta Microbiol Immunol Hung, 51:3, 263-9.
  • Bandres, E., Pombo, I., Gonzalez, H.M., 2005, “Association between bone mineral density and polymorphisms of the VDR, ERalpha, COL1A1 and CTR genes in Spanish postmenopausal women”, J Endocrinol Invest, 28:4, 312-21.
  • Bank, I., Libourel, E.J., Middeldorp, S., 2004, “Prothrombin 20210A Mutation : A Mild Risk Factor for Venous Thromboembolism but Not for Arterial Thrombotic Disease and Pregnancy-Related Complications in a Family Study”, Arch Intern Med, 164, 1932-37.
  • Barber, R.C., Aragaki, C.C., Chavez, F.A.R., 2004, “TLR-4 and TNF- polymorphisms are associated with an increased risk for severe sepsis following burn injury”, J Med Genet, 41, 808-13.
  • Bartke, Antebi, The endocrine regulation of aging by insulin-like signals, Science 2003 Feb 28;299(5611):1346-51.
  • Bartsch, H., U. Nair, et al. (2000). Genetic polymorphism of CYP genes, alone or in combination, as a risk modifier of tobacco-related cancers. Cancer Epidemiol Biomarkers Prev 9(1): 3-28.
  • Basso, F., Lowe, G. D., Rumley, A., McMahon, A. D., Humphries, S. E., 2002, “Interleukin-6 -174G>C polymorphism and risk of coronary heart disease in West of Scotland coronary prevention study (WOSCOPS)”, Arterioscler Thromb Vasc Biol 22, 599-604.
  • Bastain, T. M., Gilliland, F. D., Li, Y. F., Saxon, A., and Diaz-Sanchez, D. (2003). Intraindividual reproducibility of nasal allergic responses to diesel exhaust particles indicates a susceptible phenotype. Clin Immunol 109,130-136.
  • Bathum L, von Bornemann Hjelmborg J, Christiansen L, 2004, “Evidence for an association of methylene tetrahydrofolate reductase polymorphism C677T and an increased risk of fractures: results from a populationbased Danish twin study,” Osteoporos Int,15:8,659-64.
  • Bell CG, Walley AJ, Froguel P. The genetics of human obesity. Nature Reviews: Genetics 2005; 6(3):221–34.
  • Belsky DW, Moffitt TE, Houts R, Bennett GG, Biddle AK, Blumenthal JA, et al. Polygenic Risk, Rapid Childhood Growth, and the Development of ObesityEvidence From a 4-Decade Longitudinal StudyPolygenic Risk for Adult Obesity. Archives of Pediatrics & Adolescent Medicine. 2012;166(6):515-21.
  • Bennermo , M., Held, C., Stemme, S., 2004, “Genetic predisposition of the IL-6 response to inflammation : implications for a variety of major diseases”, Clin Chem, 50:11, 2136-40.
  • Bernad, M., Martinez, M. E., Escalona, M., Gonzalez, M. L., Gonzalez, C., Garces, M. V., Del Campo, M. T., Martin Mola, E., Madero, R., and Carreno, L. (2002). Polymorphism in the type I collagen (COLIA1) gene and risk of fractures in postmenopausal women. Bone 30, 223-228.
  • Berthier, M.T., Paradis, A.M., Tchernof, A., 2003, “The IL-6 -174 G/C polymorphism is associated with indices of obesity in men”, J Hum Genet, 48, 14-19.
  • Bhagirath KM, Hurst RT, Lester SJ. Cardiovascular risk assessment in the asymptomatic individual: a casebased approach. Coron Artery Dis. 2012 Jun;23(4):298-302.
  • Biological Aging Measurement, Clinical Applications. Ward Dean, M.D. 1988.
  • Bjorksten J, Tenhu H. The crosslinking theory of aging–added evidence. Exp Gerontol 1990; 25L 91-5.
  • Bjorksten J. The crosslinkage theory of aging, Finska Kemists Medd, 1971, 80:23-38. • Blom, J.W., Doggen, C.J.M., Osanto, S., 2005, “Malignancies, Prothrombotic Mutations, and the Risk of Venous Thrombosis”, JAMA, 293, 715-22
  • Boduroglu, K., Alanay, Y., Alikasifoglu, M., 2005, “Analysis of MTHFR 1298 A>C in addition to MTHFR 677 C>T polymorphism as a risk factor for neural tube defects in the Turkish population”, Turk J Pediatr, 47:4, 327-33.
  • Boekholdt, S.M., Sacs, F.M., Jukema, J.W., 2005, “Cholesteryl Ester Transfer Protein TaqIB Variant, High- Density Lipoprotein Cholesterol Levels, Cardiovascular Risk, and Efficacy of Pravastatin Treatment”, Circulation, 111, 278-8.
  • Boffetta P, Winn DM, Ioannidis JP, Thomas DC, Little J, Davey Smith G, et al. Recommendations and proposed guidelines for assessing the cumulative evidence on joint effects of genes and environments on cancer occurrence in humans. Int J Epidemiol. 2012.
  • Bookman EB, McAllister K, Gillanders E, Wanke K, Balshaw D, Rutter J, et al. Gene-environment interplay in common complex diseases: forging an integrative model-recommendations from an NIH workshop. Genet Epidemiol. 2011. Epub 2011/02/11.
  • Boright AP, Paterson AD, Mirea L, Bull SB, Mowjoodi A, Scherer SW, Zinman B; DCCT/EDIC Research Group. Genetic variation at the ACE gene is associated with persistent microalbuminuria and severe nephropathy in type 1 diabetes: the DCCT/EDIC Genetics Study. Diabetes. 2005 Apr;54(4):1238-44.
  • Bose, C., Guo, J., Zimniak, L., Srivastava, S.K., Singh, S.P., Zimniak, P. & Singh, S.V. (2002) Critical role of allyl groups and disulfide chain in induction of Pi class glutathione transferase in mouse tissues in vivo by diallyl disulfide, a naturally occurring chemopreventive agent in garlic. Carcinogenesis, 23, 1661-1665.
  • Botto, L. D., and Yang, Q. (2000). 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review. Am J Epidemiol 151, 862-877.
  • Bouchard C, Perusse L, Leblanc C, Tremblay A, Theriault G. Inheritance of the amount and distribution of human body fat. Int J Obes. 1988;12:205-215.
  • Bousquet J, Anto JM, Sterk PJ, Adcock IM, Chung KF, Roca J, et al. Systems medicine and integrated care to combat chronic noncommunicable diseases. Genome Med. 2011;3(7):43.
  • Bowron, A., Scott, J., Stansbie, D., 2005, “The influence of genetic and environmental factors on plasma homocysteine concentrations in a population at high risk for coronary artery disease”, Ann Clin Biochem, 42:6, 459-62.
  • Brand, E., Schorr, U., Kunz, I., Kertmen, E., Ringel, J., Distler, A., and Sharma, A. M. (2001). Tumor necrosis factor-alpha–308 G/A polymorphism in obese Caucasians. Int J Obes Relat Metab Disord 25, 581-585.
  • Brian F. Gage, Pharmacogenetics-based coumarin therapy. Hematology Am Soc Hematol Educ Program. 2006;:467-73.
  • Brigham and Women’s Hospital (BWH). Obesity in women. A guide to assessment and management. Boston (MA): Brigham and Women’s Hospital; 2003.
  • Brousseau, M.E., O’Connor, J.J., Ordovas, J.M., 2002, “CETP Taq1 B2B2 genotype is associated with higher HDL cholesterol levels and lower risk of coronary heart disease end points in men with HDL deficiency”, Arterioscler Thromb Vasc Biol, 22, 1148-54.
  • Brown, C. A., McKinney, K. Q., Kaufman, J. S., Gravel, R. A., and Rozen, R. (2000). A common polymorphism in methionine synthase reductase increases risk of premature coronary artery disease. J Cardiovasc Risk 7,197-200.
  • Brown, M. A., Haughton, M. A., Grant, S. F., Gunnell, A. S., Henderson, N. K., and Eisman, J. A. (2001). Genetic control of bone density and turnover: role of the collagen 1alpha1, estrogen receptor, and vitamin D receptor genes. J Bone Miner Res 16, 758-764.
  • Brown, S., Ordovas, J. M., Campos, H. (2003). Interaction between the APOC3 gene promoter polymorphisms, saturated fat intake and plasma lipoproteins. Atherosclerosis, 170: 307-313.
  • Brull, D. J., Lesson, C. P., Montgomery, H. E., Mullen, M., deDivitiis, M., Humphries, S. E., and Deanfield, J. E. (2002). The effect of the Interleukin-6-174G > C promoter gene polymorphism on endothelial function in healthy volunteers. Eur J Clin Invest 32, 153-157.
  • Brunotto M, Zarate AM, Bono A, Barra JL, Berra S. Risk genes in head and neck cancer: A systematic review and meta-analysis of last 5years. Oral Oncol. 2014 Mar;50(3):178-188.
  • Building on our inheritance – Genomic technology in healthcare. A report by the Human Genomics Strategy Group. 2012.
  • Buntin MB, Jain SH, Blumenthal D. Health information technology: laying the infrastructure for national health reform. Health Affairs. 2010;29(6):1214-9.
  • Burke W, Burton H, Hall AE, Karmali M, Khoury MJ, Knoppers B, et al. Extending the reach of public health genomics: what should be the agenda for public health in an era of genome-based and “personalized” medicine? Genet Med. 2010;12(12):785-91. Epub 2010/12/30. PubMed PMID: 21189494.
  • Burke W, Khoury MJ, Stewart A, Zimmern RL. The path from genome-based research to population health: development of an international public health genomics network. Genet Med. 2006;8(7):451-8. Epub 2006/07/18.
  • Burke W. Genetic testing in primary care. Annu Rev Genomics Hum Genet. 2004;5:1-14.
  • Burzotta, F., Leone, A.M., Paciaroni, K., 2004, “G20210A prothrombin gene variant and clinical outcome in patients with a first acute coronary syndrome”, Hematologica, 89, 1134-38.
  • Butkiewicz, D., E. Grzybowska, et al. (2000). Polymorphisms of the GSTP1 and GSTM1 genes and PAH DNA adducts in human mononuclear white blood cells. Environ Mol Mutagen 35(2): 99-105.
  • Buzzetti, R., Petrone, A., Caiazzo, A.M., 2005, “PPAR-_2 Pro12Ala Variant Is Associated with Greater Insulin Sensitivity in Childhood Obesity”, Pediatr Res, 57:1, 138-40.
  • Buzzetti, R., Petrone, A., Ribaudo, B.C., 2004, “The common PPAR-gamma2 Pro12Ala variant is associated with greater insulin sensitivity”, Eur J Hum Genet, 12:12, 1050-4.
  • Cai, Q., Shu, X.O., Wen, W., 2004, “Genetic polymorphism in the MnSOD gene, antioxidant intake, and breast cancer risk: results from the Shanghai breast cancer study”, Breast Can Res, 6, 647-655.
  • Calefato JM, Nippert I, Harris HJ, Kristoffersson U, Schmidtke J, Ten Kate LP, Anionwu E, Benjamin C, Challen K, Plass AM, Harris R, Julian-Reynier C. Assessing educational priorities in genetics for general practitioners and specialists in five countries: factor structure of the Genetic-Educational Priorities (Gen-EP) scale. Genet Med. 2008 Feb;10(2):99-106.
  • Calle EE, Thun MJ, Petrelli JM, Rodriguez C, Heath CWJ. Body-mass index and mortality in a prospective cohort of U.S. adults. N Engl J Med. 1999;341:1097-1105.
  • Capaccio P, Ottaviani F, Cuccarini V, “Association between methylenetetrahydrofolate reductase polymorphisms, alcohol intake and oropharyngolaryngeal carcinoma in northern Italy”, J Laryngol Otol. 2005;119:5,371-6.
  • Caramori, M.L., Canani, L.H., Costa, L.A., 2003, “The human peroxisome proliferator-activated receptor gamma2 (PPARgamma2) Pro12Ala polymorphism is associated with decreased risk of diabetic nephropathy in patients with type 2 diabetes”, Diabetes, 52:12, 3010-3.
  • Cardiometabolic Risk Working Group: Executive Committee, Leiter LA, Fitchett DH, Gilbert RE, Gupta M, Mancini GB, McFarlane PA, Ross R, Teoh H, Verma S, Anand S, Camelon K, Chow CM, Cox JL, Després JP, Genest J, Harris SB, Lau DC, Lewanczuk R, Liu PP, Lonn EM, McPherson R, Poirier P, Qaadri S, Rabasa- Lhoret R, Rabkin SW, Sharma AM, Steele AW, Stone JA, Tardif JC, Tobe S, Ur E. Identification and management of cardiometabolic risk in Canada: a position paper by the cardiometabolic risk working group (executive summary). Can J Cardiol. 2011 Mar-Apr;27(2):124-31.
  • Carmena, R.R., Ascaso, J.F., Real, J.T., 2001, “Association between the TaqIB polymorphism in the cholesteryl ester transfer protein gene locus and plasma lipoprotein levels in familial hypercholesterolemia”, 50:6, 651-6.
  • Carreon, A.A.R., Zuniga, J., Pacheco, G.H., 2005, “TNF- -308 promoter polymorphism contributes independently to HLA alleles in the severity of rheumatoid arthritis in Mexicans”, J Autoimmunity, 24, 63-8.
  • Cawthon RM, Smith KR, O’Brien E, Sivatchenko A, Kerber RA. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet. 2003 Feb 1;361(9355):393-5.
  • Cesuroglu T, Brand A. Implementation of Personalized Healthcare in Health Services in the Context of Public Health Genomics–Looking for the Broader Picture. The EPMA journal. 2011;2(Suppl 1):79-80.
  • Cesuroglu T, Karaca S, Erge S. A practice model for personalized healthcare with a public health genomics perspective. Personalized Medicine. 2009;6(5):567-77. doi: 10.2217/pme.09.37.
  • Cesuroglu T, Savas S, Mooré SA, Brand A. Implementation of Personalized Health Care in Health Systems. In: Abstract Book of the Genetica Retraite, 2012 Mar 15-16, Maastricht University; Rolduc-Kerkrade, the Netherlands, p.26.
  • Cesuroglu T, van Ommen B, Malats N, Sudbrak R, Lehrach H, Brand A. Public health perspective: from personalized medicine to personal health. Personalized Medicine. 2012.
  • Cesuroglu T. Chronic Complex Diseases and Genetics. In: Abstracts: Turkish Society of Molecular Medicine, Third International Congress of Molecular Medicine, May 5-8, 2009, Istanbul, Turkey. IUBMB Life 61(3):201-14, 2009.
  • Cesuro lu T. The Relationship Between Nutrition, Disease & Aging: A Review. Turkiye Klinikleri Journal of Medical Sciences. 2009;29(5):45.
  • Chaaba, R., Smaoui, M., Hammami, S., 2004, “Role of CETP activity and genetic polymorphism in ischemic heart disease in type 2 diabetic patients”, Tunis Med, 82:3, 282-8.
  • Chacko, P., Joseph, T., Mathew, B.S., 2005, “Role of xenobiotic metabolizing gene polymorphisms in breast cancer susceptibility and treatment outcome”, Mut Res, 581, 153-63.
  • Challen K, Harris HJ, Julian-Reynier C, et al. Genetic education and nongenetic health professionals: educational providers and curricula in Europe. Genet Med 2005;7:302–310.
  • Chang, Y., Niu, X.M., Qi, X.M., 2005, “Study in the association between gestational diabetes mellitus and TNF-gene polymorphism”, Zhonghua, Fu Chan Ke Za Zhi, 40:10, 676-8.
  • Chen, H. Y., Chen, W. C., Hsu, C. D., Tsai, F. J., and Tsai, C. H. (2002). Relation of vitamin D receptor FokI start codon polymorphism to bone mineral density and occurrence of osteoporosis in postmenopausal women in Taiwan. Acta Obstet Gynecol Scand 81, 93-98.
  • Chen, H. Y., Chen, W. C., Hsu, C. D., Tsai, F. J., Tsai, C. H., and Li, C. W. (2001). Relation of BsmI vitamin D receptor gene polymorphism to bone mineral density and occurrence of osteoporosis in postmenopausal Chinese women in Taiwan. Osteoporos Int 12, 1036-1041.
  • Chen, J., Stampfer, M. J., Ma, J., Selhub, J., Malinow, M. R., Hennekens, C. H., and Hunter, D. J. (2001). Influenceof a methionine synthase (D919G) polymorphism on plasma homocysteine and folate levels and relation to risk of myocardial infarction. Atherosclerosis 154, 667-672.
  • Chen, K., Jiang, Q.T., He, H.Q., 2005, “Relationship between metabolic enzyme polymorphism and colorectal cancer”, World J Gastroenterol, 11:3, 331-5.
  • Chen, P., Jou, Y.S., Fann, C.S.J., 2005, “Lipoprotein lipase gene is linked and associated with hypertension in Taiwan young-onset hypertension genetic study”, J Biomed Sci, 12, 651-8.
  • Chen, W., Srinivasan, S.R., Elkasabany, A., 2001, “Influence of lipoprotein lipase serine 447 stop polymorphism on tracking of triglycerides and HDL cholesterol from childhood to adulthood and familial risk of coronary artery disease: the Bogalusa Heart Study”, Atherosclerosis, 159, 367-73.
  • Cherkas LF, Hunkin JL, Kato BS, Richards JB, Gardner JP, Surdulescu GL, Kimura M, Lu X, Spector TD, Aviv A. The association between physical activity in leisure time and leukocyte telomere length. Arch Intern Med. 2008 Jan 28;168(2):154-8.
  • Chhabra, S., Narang, R., Krishnan, L.R., 2002, “Apolipoprotein C3 SstI polymorphism and triglyceride levels in Asian Indians”, BMC Genet, 3:9, 1-6.
  • Chhabra, S., Narang, R., Lakshmy, R., 2004, “Apolipoprotein C3 SstI polymorphism in the risk assesment of CAD”, Mol Cell Biochem, 259, 59-66.
  • Chistyakov, D. A., K. V. Savost’anov, et al. (2001). Polymorphisms in the Mn-SOD and EC-SOD genes and their relationship to diabetic neuropathy in type 1 diabetes mellitus. BMC Med Genet 2(1): 4.
  • Chiu, K. C., Chuang, L. M., and Yoon, C. (2001). The vitamin D receptor polymorphism in the translation initiation codon is a risk factor for insulin resistance in glucose tolerant Caucasians. BMC Med Genet 2, 2.
  • Chiuve SE, Giovannucci EL, Hankinson SE, 2005,”Alcohol intake and methylenetetrahydrofolate reductase polymorphism modify the relation of folate intake to plasma homocysteine”, Am J Clin Nutr.,82:1,155-62.
  • Chuang, L. M., Hsiung, C. A., Chen, Y. D., Ho, L. T., Sheu, W. H., Pei, D., Nakatsuka, C. H., Cox, D., Pratt, R. E., Lei, H.H., and Tai, T. Y. (2001). Sibling-based association study of the PPARgamma2 Pro12Ala polymorphism and metabolic variables in Chinese and Japanese hypertension families: a SAPPHIRe study. Stanford Asian-Pacific Program in Hypertension and Insulin Resistance. J Mol Med 79, 656-664.
  • Chung, H. Y., Kim, H. J., Kim, J. W., and Yu, B. P. (2001). The inflammation hypothesis of aging: molecularmodulation by calorie restriction. Ann N Y Acad Sci 928, 327-335.
  • Chung, H.W., Seo, J.S., Hur, S.E., 2003, “Association of IL-6 promoter variant with bone mineral density in pre-menopausa women”, J Hum Genet, 43, 243-48.
  • Clee, S.M., Loubser, O., Collins, J., 2001, “The LPL S447X cSNP is associated with decreased blood pressure and plasma triglycerides, and reduced risk of coronary artery disease”, Clin Genet, 60, 293-300.
  • Closas, M.G., Malats, N., Silverman, D., 2005, “NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses”, Lancet, 366, 649-59.
  • Colditz GA, Atwood KA, Emmons K, Monson RR, Willett WC, Trichopoulos D, Hunter DJ. Harvard report on cancer prevention volume 4: Harvard Cancer Risk Index. Risk Index Working Group, Harvard Center for Cancer Prevention. Cancer Causes Control. 2000 Jul;11(6):477-88.
  • Collins F. Genetics: an explosion of knowledge is transforming clinical practice. Geriatrics 1999; 54: 41–47.
  • Collins F. Has the revolution arrived? Nature. 2010;464(7289):674-5.
  • Collins F. Preparing health professionals for the genetic revolution. JAMA 1997; 278: 1285–1286.
  • Collins FS, Guttmacher AE. Genetics moves into the medical mainstream. JAMA. 2001 Nov 14;286(18):2322-4.
  • Collins FS, McKusick VA. Implications of the human genome project for medical science. JAMA, Vol. 285, 2001, pp. 540-545.
  • Collins FS. Reengineering translational science: the time is right. Sci Transl Med. 2011;3(90):90cm17.
  • Collins GC, Altman DG, External validation of QDSCORE for predicting the 10-year risk of developing Type 2 diabetes., Diabet. Med. 28, 599-607 (2011).
  • Collins GS, Altman DG, An independent and external validation of QRISK2 cardiovascular disease risk score: a prospective open cohort study, BMJ 2012;340:c2442.
  • Collins GS, Moons KGM. Comparing risk prediction models. Bmj. 2012;344.
  • Colombo, M.G., Paradossi, U., Andreassi, M.G., 2003, “Endothelial Nitric Oxide Synthase Gene Polymorphisms and Risk of Coronary Artery Disease”, Clin Chem, 49:3, 389-95.
  • Das, U. N. (2000). Beneficial effect(s) of n-3 fatty acids in cardiovascular diseases: but, why and how?Prostaglandins Leukot Essent Fatty Acids 63, 351-362.
  • Daskalopoulou SS, Khan NA, Quinn RR, Ruzicka M, McKay DW, Hackam DG, Rabkin SW, Rabi DM, Gilbert RE, Padwal RS, Dawes M, Touyz RM, Campbell TS, Cloutier L, Grover S, Honos G, Herman RJ, Schiffrin EL, Bolli P, Wilson T, Feldman RD, Lindsay MP, Hemmelgarn BR, Hill MD, Gelfer M, Burns KD, Vallée M, Prasad GV, Lebel M, McLean D, Arnold JM, Moe GW, Howlett JG, Boulanger JM, Larochelle P, Leiter LA, Jones C, Ogilvie RI, Woo V, Kaczorowski J, Trudeau L, Bacon SL, Petrella RJ, Milot A, Stone JA, Drouin D, Lamarre- Cliché M, Godwin M, Tremblay G, Hamet P, Fodor G, Carruthers SG, Pylypchuk G, Burgess E, Lewanczuk R, Dresser GK, Penner B, Hegele RA, McFarlane PA, Sharma M, Campbell NR, Reid D, Poirier L, Tobe SW; Canadian Hypertension Education Program. The 2012 Canadian hypertension education program recommendations for the management of hypertension: blood pressure measurement, diagnosis, assessment of risk, and therapy. Can J Cardiol. 2012 May;28(3):270-87.
  • Davies, S. M., L. L. Robison, et al. (2000). Glutathione S-transferase polymorphisms in children with myeloid leukemia: a Children’s Cancer Group study. Cancer Epidemiol Biomarkers Prev 9(6): 563-6.
  • Davies, S. M., L. L. Robison, et al. (2001). Glutathione S-transferase polymorphisms and outcome ofchemotherapy in childhood acute myeloid leukemia. J Clin Oncol 19(5): 1279-87.
  • Davignon, J, Gregg RE, Sing CF. (1988) Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis 8:1–21.
  • De Grey ADNJ. Molecular Biology Intelligence Unit: The Mitochondrial Free Radical Theory of Aging. 1999. Landes Company.
  • Dedoussis, G.V., Panagiotakos, G.B., Vidra, N.V., 2005, Associations between TNF- -308 G>A polymorphism and the developement of acute coronary syndromes in Grek subjects”, Genet Med, 7:6, 411-6.
  • Degoul, F., Sutton, A., et. al. (2001) Homozygosity for alanine in the mitochondrial targeting sequence ofsuperoxide dismutase and risk for severe alcoholic disease. Gastroenterology 120: 1468-74.
  • Del Fiol G, Williams MS, Maram N, Rocha RA, Wood GM, Mitchell JA. Integrating genetic information resources with an EHR. AMIA Annu Symp Proc. 2006:904.
  • del Sol A, Balling R, Hood L, Galas D. Diseases as network perturbations. Curr Opin Biotechnol. 2010;21(4):566-71.
  • Delbanco, E. H., H. M. Bolt, et al. (2001). Glutathione transferase activities in renal carcinomas and adjacent normal renal tissues: factors influencing renal carcinogenesis induced by xenobiotics. Arch Toxicol 74(11):688- 94.
  • Dengel, D. R., Brown, M. D., Ferrell, R. E., Reynolds, T. H. t., and Supiano, M. A. (2002). Exercise-induced changes in insulin action are associated with ACE gene polymorphisms in older adults. Physiol Genomics 11, 73-80.
  • Dennison, E. M., Arden, N. K., Keen, R. W., Syddall, H., Day, I. N., Spector, T. D., and Cooper, C. (2001). Birthweight, vitamin D receptor genotype and the programming of osteoporosis. Paediatr Perinat Epidemiol 15, 211-219.
  • Denny JC, Ritchie MD, Basford MA, Pulley JM, Bastarache L, Brown-Gentry K, et al. PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations. Bioinformatics. 2010;26(9):1205- 10.
  • Dentali. F., Crowther. M., Ageno. W., 2006, “Thrombophilic abnormalities, oral contraceptives, and risk of cerebral vein thrombosis: a meta-analysis.”, Blood, 1;107(7):2766-73.
  • Department of Health UK. Innovation, Health and Wealth, Accelerating Adoption and Diffusion in the NHS. 2011 5 Dec 2011.Desmond-Hellmann S. Toward Precision Medicine: A New Social Contract? Sci Transl Med. 2012;4(129):129ed3.
  • Diabetes type 1 and 2 evidence-based nutrition practice guideline for adults. Chicago (IL): American Dietetic Association; 2008.
  • Dilley, A., Austin, H., El-Jamil, M., 2000, “Genetic factors associated with thrombosis in pregnancy in a United States population”, Am J Obstet Gynecol, 183, 1271-7.
  • Dilman Vladimir, Dean Ward. The Neuroendocrine Theory of Aging, The Center for Bio-Gerontology, Pensacola, 1992.
  • Diyabet 2020: Vizyon ve Hedefler. Türkiye Diyabet Vakfı, 2010. (T.C. Sa lık Bakanlı ı himayelerinde, Dünya Sa lık Örgütü Avrupa (WHO Europe) ve Uluslararası Diyabet Federasyonu Avrupa (IDF Europe) i birli i ile Türkiye Diyabet Vakfı koordinatörlü ünde yürütülmü onal projenin nihai sonucudur)
  • Djoussé L, Pankow JS, Arnett DK, Eckfeldt JH, Myers RH, Ellison RC. Apolipoprotein E polymorphism modifies the alcohol-HDL association observed in the National Heart, Lung, and Blood Institute Family Heart Study. Am J Clin Nutr. 2004 Dec;80(6):1639-44.
  • Doney, A.S.F., Fischer, B., Leese, G., 2004, “Cardiovascular Risk in Type 2 Diabetes Is Associated With Variation at the PPARG Locus”, Arterioscler Thrombos Vasc Biol, 24, 2403-7.
  • Douglas, J.A., Erdos, M.R., Watanabe, R.M., 2001, “The peroxisome proliferator-activated receptor-gamma2 Pro12A1a variant: association with type 2 diabetes and trait differences”, Diabetes, 50:4, 886-90.
  • Draghia-Akli R. Enabling personalized medicine in Europe: a look at the European Commission’s funding activities in the field of personalized medicine research. Personalized Medicine. 2012;9(2):151-5.
  • Dresler, C. M., C. Fratelli, et al. (2000). Gender differences in genetic susceptibility for lung cancer. Lung Cancer 30(3): 153-60.
  • Duff, G.W. (2006) Evidence for genetic variation as a factor in maintaining health. Am J Clin Nutr. 83(2):431S- 435S.
  • Dugi, K. A., Brandauer, K., Schmidt, N., Nau, B., Schneider, J. G., Mentz, S., Keiper, T., Schaefer, J. R., Meissner, C., Kather, H., Bahner, M. L., Fiehn, W., Kreuzer, J. (2001). Low hepatic lipase activity is a novel risk factor for coronary arterydisease. Circulation. 18;104(25):3057-62.
  • Dusinska, M., Ficek, A., Horska, A., 2001, “Glutathione S-transferase polymorphisms influence the level of oxidative DNA damage and antioxidant protection in humans”, Mut Res, 482, 47-55.
  • EAPM. Innovation and Patient Access to Personalised Medicine – Report from Irish Presidency Conference March 20th/21st 2013. Brussels: European Alliance for Personalised Medicine; 2013.
  • Eastell, R., and Lambert, H. (2002a). Diet and healthy bones. Calcif Tissue Int 70, 400-404. Eastell, R., and Lambert, H. (2002b). Strategies for skeletal health in the elderly. Proc Nutr Soc 61, 173-180.
  • Egan, K.M., Cai, Q., Shu, X.O., 2004, “Genetic Polymorphisms in GSTM1, GSTP1, and GSTT1 and the Risk for Breast Cancer: Results from the Shanghai Breast Cancer Study and Meta-Analysis”, Canc Epidemiol Biomark Prev,13, 197-204.
  • Eicher, J. E., Dunn, S. T., Perveen, G., et al. (2002). Apolipoprotein E Polymorphism and Cardiovascular Disease: A HuGE Review. American Journal of Epidemiology, 155 (6): 487-495.
  • Ek, J., Andersen, G., Urhammer, S.A., 2001, “ Studies of the Pro12Ala polymorphism of the PPAR gamma 2 gene in relation to insulin sensitivity among glucose tolerant Caucasians”, Diabetologia, 44, 1170-6. • Ellsworth DL, Coady SA, Chen W, Srinivasan SR, Elkasabany A, Gustat J, Boerwinkle E, and Berenson GS. Influence of the beta2-adrenergic receptor Arg16Gly polymorphism on longitudinal changes in obesity from childhood through young adulthood in a biracial cohort: the Bogalusa Heart Study. Int J Obes Relat Metab Disord 26: 928-937, 2002.
  • Emery J, Hayflick S. The challenge of integrating genetic medicine into primary care. BMJ 2001; 322: 1027– 1030.
  • Encyclopedia of Aging, 4-vol., David J. Ekerdt, Editor in Chief, Macmillan Reference USA, Thomson & Gale, 2002.
  • Endothelial Nitric Oxide Synthase Gene with Essential Hypertension Resistant to Conventional.
  • Eriksson, J. G., Lindi, V., Uusitupa, M., Forsen, T. J., Laakso, M., Osmond, C., and Barker, D. J. (2002). The effects of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 gene on insulin sensitivity and insulin metabolism interact with size at birth. Diabetes 51, 2321-2324.
  • ESF Forward Look – Personalised Medicine for the European Citizen. Strasbourg, France: European Science Foundation; 2012.
  • Espinel, E., Tovar, J.L., Borrellas, J., 2005, “Angiotensin-converting enzyme i/d polymorphism in patients with malignant hypertension”, J Clin Hypertens, 7:1, 11-15.
  • European Health Forum Gastein. The Big Data Workshop, 16th European Health Forum Gastein [Report]: European Health Forum Gastein; 2013.
  • Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Working Group. Recommendations from the EGAPP Working Group: genomic profiling to assess cardiovascular risk to improve cardiovascular health. Genet Med 2010 Dec;12(12):839-43.
  • Evans J, Khoury MJ. Evidence based medicine meets genomic medicine. Genet Med. 2007;9(12):799-800.
  • Expert panel on integrated guidelines for cardiovascular health and risk reduction in children and adolescents. Bethesda (MD): National Heart, Lung, and Blood Institute; 2011.
  •  Farin, F. M., Y. Hitosis, et al. (2001). Genetic polymorphisms of superoxide dismutase in Parkinson’s disease.Mov Disord 16(4): 705-7.
  • Farooqi IS. Genetic and hereditary aspects of childhood obesity. Best Practice and Research Clinical Endocrinology and Metabolism 2005; 19(3):359–374.
  • FDA Approves Updated Warfarin (Coumadin) Prescribing Information, Press Release of FDA, August 16, 2007.
  • Feero WG, Green ED. Genomics education for health care professionals in the 21st century. Jama. 2011;306(9):989-90.
  • Feero WG, Guttmacher AE, Collins FS. Genomic medicine–an updated primer. N Engl J Med. 2010;362(21):2001-11.
  • Feix, A., Polanz, F.R., Kleytzmar, J., 2001, “Increased prevalence of combined MTR and MTHFR genotypes among individuals with severely elevated total homocysteine plasma levels”, Am J Kidney Dis, 38:5, 956-64.
  • Feng, Y., Niu, T., Xu, X., 2002, “Insertion/Deletion Polymorphism of the ACE Gene Is Associated With Type 2 Diabetes”, Diabetes, 51, 1986-88.
  • Fennell, T. R., J. P. MacNeela, et al. (2000). Hemoglobin adducts from acrylonitrile and ethylene oxide in cigarette smokers: effects of glutathione S-transferase T1-null and M1-null genotypes. Cancer Epidemiol Biomarkers Prev 9(7): 705-12.
  • Ferencak, G., Pasalic, D., Grskovic, B., 2003, “Lipoprotein lipase gene polymorphisms in Croatian patients with coronary artery disease”, Clin Chem Lab Med, 41:4, 541-6.
  • Ferrari, S. L. (2001). Osteoporosis, vitamin D receptor gene polymorphisms and response to diet. World Rev Nutr Diet 89, 83-92.
  • Ferrari, S. L., Garnero, P., Emond, S., Montgomery, H., Humphries, S. E., and Greenspan, S. L. (2001). A functional polymorphic variant in the interleukin-6 gene promoter associated with low bone resorption in postmenopausal women. Arthritis Rheum 44, 196-201.
  • Fifth Joint Task Force of the European Society of Cardiology; European Association of Echocardiography; European Association of Percutaneous Cardiovascular Interventions; European Heart Rhythm Association; Heart Failure Association; European Association for Cardiovascular Prevention & Rehabilitation; European Atherosclerosis Society; International Society of Behavioural Medicine; European Stroke Organisation; European Society of Hypertension; European Association for the Study of Diabetes; European Society of General Practice/Family Medicine; International Diabetes Federation Europe; European Heart Network. European Guidelines on cardiovascular disease prevention in clinical practice (version 2012): the Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts). Eur J Prev Cardiol. 2012 Aug;19(4):585-667.
  • Figueiredo JC, Levine AJ, Crott JW, Baurley J, Haile RW. Folate-genetics and colorectal neoplasia: what we know and need to know next. Mol Nutr Food Res. 2013 Apr;57(4):607-27. doi: 10.1002/mnfr.201200278.
  • Finkel T, Holbrook NJ. Oxidants, oxidative stress and the biology of ageing. Nature. 2000 Nov 9;408(6809):239- 47.
  • Finkel T, Holbrook NJ. Oxidants, oxidative stress and the biology of ageing. Nature. 2000 Nov 9;408(6809):239- 47.
  • Flum D, Dellinger E. The impact of bariatric surgery on patient survival: a population-based analysis. American College of Surgeons 89th Annual Clinical Congress, 19–23 October 2003, Chicago, Illinois.
  • Foka, Z.J., Lambropoulos, A.F., Saravelos, H., 2000, “ Factor V leisen and prothrombin G20210A mutations, but not MTHFR C677T are associated with recurrent miscarriages”, Hum Repr, 15:2, 458-62.
  • Fontova, R., Gutierrez, C., Vendrell, J., Broch, M., Vendrell, I., Simon, I., Fernandez-Real, J. M., and Richart, C. (2002). Bone mineral mass is associated with interleukin 1 receptor autoantigen and TNF-alpha gene polymorphisms in post-menopausal Mediterranean women. J Endocrinol Invest 25, 684-690.
  • Ford, J.G., Li, Y., O’Sullivan, M.M., 2000, “ GSTM1 polymorphism and lung cancer risk in African-Americans”, Carcinogenesis, 21:11, 1971-5.
  • Frazier, L., Johnson, R.L., Sparks, E. (2005) Genomics and cardiovascular disease. J Nurs Scholarsh;37(4):315-21.
  • Frazier, L., Johnson, R.L., Sparks, E. (2005) Genomics and cardiovascular disease. J Nurs Scholarsh;37(4):315-21.
  • Frederiksen, L., Brodbek, K., Fenger, M., 2002, “Studies of the Pro12Ala Polymorphism of the PPAR G Gene in the Danish MONICA Cohort: Homozygosity of the Ala Allele Confers a Decreased Risk of the Insulin Resistance Syndrome”, J Clin Endocrinol Metabol, 87, 3789-92.
  • Frenk J, Bobadilla JL, Stern C, Frejka T and Lozano R. Elements for a theory of the health transition.. Ch. 2 in: Chen LC, Kleinman A and Ware NC (eds): Health and social change in international perspective. Harvard Series on population and international health. Harvard University Press, Boston, 1993.
  • Frosch D, Mello P, Lerman C. Behavioral consequences of testing for obesity risk. Cancer Epidemiol Biomarkers Prev 14: 1485-1489, 2005.
  • Gadelha, T., Andre, C., Juca, A.A., Nucci, M., 2005, “Prothrombin 20210A and oral contraceptive use as risk factors for cerebral venous thrombosis”, Cerebrovasc Dis. 19(1):49-52.
  • Galas DJ, Hood L. Systems Biology and Emerging Technologies Will Catalyze the Transition from Reactive Medicine to Predictive, Personalized, Preventive and Participatory (P4) Medicine. Interdisciplinary Bio Central. 2009;1(2):1-4.
  • Gao Y, Cao Y, Tan A, Liao C, Mo Z, Gao F. Glutathione S-transferase M1 polymorphism and sporadic colorectal cancer risk: An updating meta-analysis and HuGE review of 36 case-control studies. Ann Epidemiol. 2010 Feb;20(2):108-21.
  • Gao, J., Shan, G., Sun, B., 2006, “Association between polymorphism of TNF- -308 gene promoter and asthma : meta analysis”, Thorax; 61(6):466-71.
  •  Gao., X., Dinkova-Kostova, A.T, Talalay, P. (2001) Powerful and prolonged protection of human retinalpigment epithelial cells, keratinocytes, and mouse leukemia cells against oxidative damage: The indirect antioxidant effects of sulforaphane. Proc. Nat. Acad. Sci. 98(26): 15221-15226.
  • Gardemann, A., Lohre, J., Cayci, S., 2002, “The T allele of the missense Glu298Asp endothelial nitric oxide synthase gene polymorphism is associated with coronary heart disease in younger individuals with high atherosclerotic risk profile”, Atheroscler, 160, 167-75.
  • Garnero, P., Borel, O., Sornay-Rendu, E., Duboeuf, F., Jeffery, R., Woo, P., and Delmas, P. D. (2002). Association between a functional interleukin-6 gene polymorphism and peak bone mineral density and postmenopausal bone loss in women: the ofely study. Bone 31, 43-50.
  • Garnero, P., Munoz, F., Borel, O., 2005, “Vitamin D receptor gene polymorphisms are associated with the risk of fractures in postmenopausal women, independently of bone mineral density”, J Clin Endocrinol, 90:8, 4829- 35.
  • Garrote, J. A., Arranz, E., Telleria, J. J., Castro, J., Calvo, C., and Blanco-Quiros, A. (2002). TNF alpha and LT alpha gene polymorphisms as additional markers of celiac disease susceptibility in a DQ2-positive population. Immunogenetics 54, 551-555.
  • Gaudet, M. M., Olshan, A. F., Poole, C., Weissler, M. C., Watson, M., and Bell, D. A. (2004). Diet, GSTM1, and GSTT1 and head and neck cancer. Carcinogenesis. Epub ahead of print.
  • Gaughan, D. J., Kluijtmans, L. A., Barbaux, S., McMaster, D., Young, I. S., Yarnell, J. W., Evans, A., and Whitehead,A. S. (2001). The methionine synthase reductase (MTRR) A66G polymorphism is a novel genetic determinantof plasma homocysteine concentrations. Atherosclerosis 157, 451-456.
  • Genome-based Research and Population Health. Report of an expert workshop held at the Rockefeller Foundation Study and Conference Centre Bellagio, Italy, 14–20 April 2005. Public Health Genetics Unit, Cambridge, UK; Institute for Public Health Genetics, University of Washington, Seattle, USA; Office of Genomics & Disease Prevention, Center for Disease Control and Prevention, Atlanta, USA 2005.
  • Gibbs W. Gaining on fat. Scientific American 1996; 275(2):88-94.
  • Gilliland, F., Li., Y.-F., Saxon, A., and Diaz-Sanchez, D. (2004). Effect of glutathione-S-transferase M1 and P1 genotypes on xenobiotic enhancement of allergic responses: randomised, placebo-controlled crossover study. Lancet 363, 119-125.
  • Ginsburg GS, Donahue, M.P., Newby, L.K. (2005) Prospects for personalized cardiovascular medicine: the impact of genomics. J Am Coll Cardiol; 46(9):1615-27.
  • Girolami A, Spiezia L, Girolami B, Zocca N, Luzzatto G., 2004, “Effect of age on oral contraceptive-induced venous thrombosis”, Clin Appl Thromb Hemost, 10(3):259-63.
  • Go VLW, Nguyen CTH, Harris DM, Lee WNP. Nutrient-Gene Interaction: Metabolic Genotype-Phenotype Relationship. Published in a supplement to The Journal of Nutrition, 2005. Presented as part of the International Research Conference on Food, Nutrition, and Cancer held in Washington, DC, July 14–15, 2005.
  • Godschalk, R. W.; Dallinga, J. W, et al. (2001b). Modulation of DNA and protein adducts in smokers by genetic polymorphisms in GSTM1,GSTT1, NAT1 and NAT2. Pharmacogenetics 11: 389-98.
  • Godschalk, R. W.; Ostertag, J. U.. et al. (2001a) Impact of GSTM1 on aromatic-DNA adducts and p53 accumulation in human skin and lymphocytes. Pharmacogenetics 11:537-43.
  • Gohda, T., Makita, Y., Shike, T., 2001, “Association of the DD genotype and development of Japanese type 2 diabetic nephropathy”, Clin Nephrol, 56:6, 475-80.
  • Gonzalez Sanchez JL, Proenza AM, Martinez Larrad MT, Ramis JM, Fernandez Perez C, Palou A, and Serrano Rios M. The glutamine 27 glutamic acid polymorphism of the beta2-adrenoceptor gene is associated with abdominal obesity and greater risk of impaired glucose tolerance in men but not in women: a population-based study in Spain. Clin Endocrinol (Oxf) 59: 476-481, 2003.
  • Gonzalez, Z.L.A.M., Vasquez, A.A., Sayed, T.F.A., 2005, “Angiotensin-converting enzyme gene insertion/deletion polymorphism and breast cancer risk”, Cancer Epidemiol Biomarkers Prev, 14:9, 2143-6.
  • Gos, M., Potocka, A.S., 2002, “Genetic basis of neural tube defects. II. Genes correlated with folate and methionine metabolism”, J Appl Genet, 43:4, 511-24.
  • Gotto AM Jr, Moon JE. Management of cardiovascular risk: the importance of meeting lipid targets. Am J Cardiol. 2012 Jul 1;110(1 Suppl):3A-14A.
  • Görman U, Mathers JC, Grimaldi KA, Ahlgren J, Nordström K. Do we know enough? A scientific and ethical analysis of the basis for genetic-based personalized nutrition. Genes Nutr. 2013 Jul;8(4):373-81.
  • Green D., 2003, “Thrombophilia and stroke”, Top Stroke Rehabil, 10(3):21-33. • Green ED, Guyer MS. Charting a course for genomic medicine from base pairs to bedside. Nature. 2011;470(7333):204-13.
  • Green MJ, Botkin JR. “Genetic exceptionalism” in medicine: clarifying the differences between genetic and nongenetic tests. Ann Intern Med. 2003;138(7):571-5.
  • Greenberg JA. Organ metabolic rates and aging: two hypotheses. Med Hypotheses 1999; 52: 15-22.
  • Greenberg T. Conference Scene: Personalized Medicine comes to Harvard. Personalized Medicine. 2011 2012/01/01;9(1):17-8.
  • Greenland P, Alpert JS, Beller GA, Benjamin EJ, Budoff MJ, Fayad ZA, Foster E, Hlatky MA, Hodgson JM, Kushner FG, Lauer MS, Shaw LJ, Smith SC Jr, Taylor AJ, Weintraub WS, Wenger NK, Jacobs AK, Smith SC Jr, Anderson JL, Albert N, Buller CE, Creager MA, Ettinger SM, Guyton RA, Halperin JL, Hochman JS, Kushner FG, Nishimura R, Ohman EM, Page RL, Stevenson WG, Tarkington LG, Yancy CW; American College of Cardiology Foundation; American Heart Association. 2010 ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2010 Dec 14;56(25):e50-103
  • Grimaldi KA, Look MP, Scioli GA, Clavero JC, Marinos S, Tagaris T. Personal genetics: regulatory framework in Europe from a service provider’s perspective. Eur J Hum Genet. 2011 Apr;19(4):382-8.
  • Grimaldi KA, McGurk CJ, McHugh PJ, Hartley JA. PCR-based methods for detecting DNA damage and its repair at the sub-gene and single nucleotide levels in cells. Molecular biotechnology. 2002;20(2):181-96.
  • Grimaldi KA, Paoli A, Smith GJ. Personal genetics: sports utility vehicle? Recent Pat DNA Gene Seq. 2012 Dec;6(3):209-15.
  • Grimble, R. F. (2001). Nutritional modulation of immune function. Proc Nutr Soc 60, 389-397.
  • Gudmundsdottir, K., Tryggvadottir, L., Eyfjord, J.E., 2001, “GSTM1, GSTT1, and GSTP1 Genotypes in Relation to Breast Cancer Risk and Frequency of Mutations in the p53 Gene”, Canc Epidemiol Biomark Prev, 10, 1169- 73.
  • Gueant, J.L., Gueant, R.R.M., Anello, G., 2003, “Genetic determinants of folate and vitamin B12 metabolism: a common pathway in neural tube defect and down syndrome”, Clin Chem Lab Med, 41:11, 1473-7.
  • Guedon, C., Duchez, L.C., Lalaude, O., 2001, “Prothrombotic Inherited Abnormalities Other Than Factor V Leiden Mutation Do Not Play a Role in Venous Thrombosis in Inflammatory Bowel Disease”, Am J Gastroeneterol, 96, 1448-54.
  • Guettier J, Georgopoulos A, Tsai M, Radha V, Shanthrani S, Deepa R, Gross M, Rao G, Mohan V. Polymorphisms in the fatty acid-binding protein 2 and apolipoprotein c-III genes are associated with the metabolic syndrome and dyslipidemia in a south Indian population. J Clin Endocrinol Metab 90: 1705-1711, 2004.
  • Gulcher J, Stefansson K. Genetic risk information for common diseases may indeed be already useful for prevention and early detection. European Journal of Clinical Investigation. 2010 Jan;40(1):56-63.
  • Gürdöl, F., bilen, E., Yılmaz, H., 2004, “The association between preeclampsia and angiotensin-converting enzyme insertion/deletion polymorphism”, Clin Chim Acta, 341, 127-31.
  • Haddock CK, Poston WS, Dill PL, Foreyt JP, Ericsson M. Pharmacotherapy for obesity: a quantitative analysis of four decades of published randomized clinical trials. Int J Obes 2002;26(2):262–73.
    • Halliday JL, Collins VR, Aitken MA, Richards MPM. Genetics and public health – evolution or revolution. J Epidemiol Community Health, Vol. 58, 2004, pp. 894-899.
  • Hallikainen M, Toppinen L, Mykkanen H, Agren J, Laaksonen D, Miettinen T, Niskanen L, Poutanen K, Gylling H. Interaction between cholesterol and glucose metabolism during dietary carbohydrate modification in subjects with the metabolic syndrome. Am J Clin Nutr 84: 1385-1392, 2006.
  • Hamburg MA, Collins FS. The path to personalized medicine. N Engl J Med. 2010;363(4):301-4.
  • Hansen, S.K., Nielsen, E.M., Ek, J., 2005, “Analysis of separate and combined effects of common variation in KCNJ11 and PPAR on risk of type 2 diabetes”, J Clin Endocr Metabol, 90:6, 3629-37.
  • Hara, K., Okada, T., Tobe, K., 2000, “The Pro12Ala Polymorphism in PPAR 2 May Confer Resistance to Type 2 Diabetes”, Biochem Biophysic Res Comm, 271, 212-216.
  • Harada, S., H. Tachikawa, et al. (2001). Glutathione S-transferase M1 gene deletion may be associated with susceptibility to certain forms of schizophrenia. Biochem Biophys Res Commun 281(2): 267-71.
  • Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol. 1956 Jul;11(3):298-300.
  • Hartman M, Suo C, Lim WY, Miao H, Teo YY, Chia KS. Ability to predict breast cancer in Asian women using a polygenic susceptibility model. Breast Cancer Res Treat. 2011;127(3):805-12.
  •  Hauner H, Meier M, Jockel KH, Frey UH, Siffert W. Pharmacogenetics. 2003 Aug;13(8):453-9. Prediction of successful weight reduction under sibutramine therapy through genotyping of the G-protein beta3 subunit gene (GNB3) C825T polymorphism.
  • Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp Cell Res. 1965;37:614–636.Comfort A.
  • He XF, Wei W, Li SX, Su J, Zhang Y, Ye XH, Liu Y, Wang W. Association between the COMT Val158Met polymorphism and breast cancer risk: a meta-analysis of 30,199 cases and 38,922 controls. Mol Biol Rep. 2012 Jun;39(6):6811-23.
  • Heil, S.G., Heijer, M.D., Pisa, V.D.R., 2004, “The 894 G > T variant of endothelial nitric oxide synthase (eNOS) increases the risk of recurrent venous thrombosis through interaction with elevated homocysteine levels”, J Thromb Haemost, 2, 750-3.
  • Henao OL, Piyathilake CJ, Waterbor JW, 2005, “ Women with polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MS) are less likely to have cervical intraepithelial neoplasia (CIN) 2 or 3.”, Int J Cancer, 113:6,991-7.
  • Herrmann, S.M., Ringel, J., Wang, J.G., 2002, “Peroxisome proliferator-activated receptor-gamma2 polymorphism Pro12Ala is associated with nephropathy in type 2 diabetes: The Berlin Diabetes Mellitus (BeDiaM) Study”, Diabetes, 51:8, 2653-7.
  • Herron, K.L., Lofgren, I.E., Adiconis, X., 2006, “Associations between plasma lipid parameters and APOC3 and APOA4 genotypes in a healthy population are independent of dietary cholesterol intake, Atherosclerosis, 184, 113-20.
  • Hippisley-Cox J, Coupland C, et al., Predicting cardiovascular risk in England and Wales: prospective derivation and validation of QRISK2, BMJ 2008;336:1475.
  • Hippisley-Cox J, Coupland C, Predicting risk of type 2 diabetes in England and Wales: prospective derivation and validation of QDScore, (since renamed QDiabetes), BMJ 2009;338:b880.
  • Hirvonen, A, Benhamou, S, et al (2001). Association between manganese superoxide dismutase (MnSOD) gene polymorphism and breast cancer risk. Carcinogenesis 5(22): 827-829.
  • Hobbs, C. A., Sherman, S. L., Yi, P., Hopkins, S. E., Torfs, C. P., Hine, R. J., Pogribna, M., Rozen, R., and James, S. J. (2000). Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome.Am J Hum Genet 67, 623-630.
  • Hobbs, C.A., James, S.J., Jernigan, S., 2006, “Congenital heart defects , maternal homocysteine, smoking and the 677 C>T polymorphism in the MTHFR gene “, Am J Obst Gynecol, 194, 218-24.
  • Hobbs, C.A., Sherman, S.L., Yi, P., 2000, “Polymorphisms in Genes Involved in Folate Metabolism as Maternal Risk Factors for Down Syndrome”, Am J Hum Genet, 67, 623-30.
  • Hobson, E. E., and Ralston, S. H. (2001). Role of genetic factors in the pathophysiology and management of osteoporosis. Clin Endocrinol (Oxf) 54, 1-9.
  • Hoffstedt, J., Eriksson, P., Hellstrom, L., Rossner, S., Ryden, M., and Arner, P. (2000). Excessive fat accumulation is associated with the TNF alpha-308 G/A promoter polymorphism in women but not in men. Diabetologia 43, 117-120.
  • Hoffstedt, J., Eriksson, P., Hellstrom, L., Rossner, S., Ryden, M., and Arner, P. (2000). Excessive fat accumulation is associated with the TNF alpha-308 G/A promoter polymorphism in women but not in men. Diabetologia 43, 117-120.
  • Hong Y.C., Lee K.H., et al. (2002) Genetic susceptibility of term pregnant women to oxidative damage.Toxicology Letters: 129(3):255-62.
  • Hood L, Friend SH. Predictive, personalized, preventive, participatory (P4) cancer medicine. Nat Rev Clin Oncol. 2011;8(3):184-7.
  • Hood L. A Doctor’s Vision of the Future of Medicine. Newsweek. 2009 Jul 13, 2009.
  • Horigan G, McNulty H, Ward M, Strain JJ, Purvis J, Scott JM. Riboflavin lowers blood pressure in cardiovascular disease patients homozygous for the 677C–>T polymorphism in MTHFR. J Hypertens. 2010;28(3):478-86.
  • Hornig, B., Landmesser, U., Kohler, C., Ahlersmann, D., Spiekermann, S., Christoph, A., Tatge, H. & Drexler, H.(2001) Comparative effect of ace inhibition and angiotensin II type 1 receptor antagonism on bioavailability of nitric oxide in patients with coronary artery disease: role of superoxide dismutase. Circulation, 103, 799-805.
  • Hubbard, R., and Fogarty, A. (2004). The developing story of antioxidants and asthma. Thorax 59, 3-4. • Hudson K. The health benefits of genomics: out with the old, in with the new. Health affairs. 2008;27(6):1612-5.
  • Hudson KL. Genomics, health care, and society. N Engl J Med. 2011;365(11):1033-41.
  • Human Genomics Laboratory, Pennington Biomedical Research Center, Louisiana State University. Obesity Gene Map Database.
  • Humphries, S. E., Luong, L. A., Ogg, M. S., Hawe, E., and Miller, G. J. (2001). The interleukin-6 -174 G/C promoter polymorphism is associated with risk of coronary heart disease and systolic blood pressure in healthy men. Eur Heart J 22, 2243-2252.
  • Hustad S, Ueland PM, Vollset SE, 2000, Riboflavin as a determinant of plasma total homocysteine: effect modification by the methylenetetrahydrofolate reductase C677T polymorphism.”,Clin Chem.46:8 ,1065-71.
  • Hyndman, M. E., Bridge, P. J., Warnica, J. W., Fick, G., and Parsons, H. G. (2000). Effect of heterozygosity for the methionine synthase 2756 A–>G mutation on the risk for recurrent cardiovascular events. Am J Cardiol 86,1144-1146, A1149.
  • Ikevaki, K., Mabuchi, H., Teramoto, T., 2003, “Association of cholesteryl ester transfer protein activity and TaqIB polymorphism with lipoprotein variations in Japanese subjects”, Metabolism, 52:12, 1564-70
  • Imamura, A., Okumura, K., Matsui, H., 2004, “Endothelial nitric oxide synthase and methylenetetrahydrofolate reductase gene polymorphisms are associated with endothelial dysfunction in young, healthy men”, Can J Cardiol, 20:12, 1229-34.
  • Inelmen EM, Toffanello ED, Enzi G, Gasparini G, Miotto F, Sergi G, Busetto L. Predictors of drop-out in overweight and obese outpatients. Int J Obes (Lond). 2005 Jan;29(1):122-8. (abstract)
  • Institute for Clinical Systems Improvement (ICSI). Prevention and management of obesity (mature adolescents and adults). Bloomington (MN): Institute for Clinical Systems Improvement (ICSI); 2005 Nov.
  • Inzucchi SE, Bergenstal RM, Buse JB, Diamant M, Ferrannini E, Nauck M, Peters AL, Tsapas A, Wender R, Matthews DR; American Diabetes Association (ADA); European Association for the Study of Diabetes (EASD). Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care. 2012 Jun;35(6):1364-79. doi: 10.2337/dc12-0413. Epub 2012 Apr 19. Review. No abstract available. Erratum in: Diabetes Care. 2013 Feb;36(2):490.
  • Isotalo, P. A., and Donnelly, J. G. (2000). Prevalence of methylenetetrahydrofolate reductase mutations in patients with venous thrombosis. Mol Diagn 5, 59-66.
  • Ivaschenko, T.E., Sidelava, O.G., Baranov, V.S., 2002, “Glutathione-S-transferase μ and theta gene polymorphisms as new risk factors of atopic bronchial asthma”, J Mol Med, 80, 39-43.
  • Jachimova, M., Horky, K., Bultas, J., 2001, “Association of the Glu298Asp polymorphism in the in the endothelial nitric oxide synthase gene with essential hypertension resistant to conventional therapy”, Biochem Biophys Res Commun, 284(2):426-30.
  • Jansen, A.C.M., Cohen, E.S.A., Tanck, M.W.H., 2005, “Genetic Determinants of Cardiovascular Disease Risk in Familial Hypercholesterolemia”, Arterioscl Thrombos Vasc Biol, 25, 1475-81.
  • Jarai, Z.K., Easton, D., Edwards, S.M. “Relationship between glutathione S-transferase M1, P1 and T1 polymorphisms and early onset prostate cancer. Pharmacogenetics. 2001 Jun;11(4):325-30.
  • Jeanmonod, P., von Kanel, R., Maly, F.E., Fischer, J.E., 2004, “Elevated Plasma C-reactive protein in chronically distressed subjects who carry the A allele of the TNF-alpha -308 G/A polymorphism”, Psychosom Med., 66(4):501-6
  • Jenny, N. S., Tracy, R. P., Ogg, M. S., Luong, L. A., Kuller, L. H., Arnold, A. M., Sharrett, A. R., and Humphries, S. E.(2002). In the Elderly, Interleukin-6 Plasma Levels and the -174G>C Polymorphism Are Associated With the Development of Cardiovascular Disease. Arterioscler Thromb Vasc Biol 22, 2066-2071.
  • Jia J, Ma Z, Wu S. Positive association between MTHFR C677T polymorphism and oral cancer risk: a meta-analysis. Tumour Biol. 2014 Feb 1.
  • Joffe YT, Collins M, Goedecke JH. The relationship between dietary fatty acids and inflammatory genes on the obese phenotype and serum lipids. Nutrients. 2013 May 21;5(5):1672-705.
  • Jones, K. G., Brull, D. J., Brown, L. C., Sian, M., Greenhalgh, R. M., Humphries, S. E., and Powell, J. T. (2001).Interleukin-6 (IL-6) and the prognosis of abdominal aortic aneurysms. Circulation 103, 2260- 2265.Jul;21(1):73-8.
  • Joost HG, Gibney MJ, Cashman KD, Gorman U, Hesketh JE, Mueller M, et al. Personalised nutrition: status and perspectives. Brit J Nutr. 2007;98(1):26-31.
  • Joshi PH, Chaudhari S, Blaha MJ, Jones SR, Martin SS, Post WS, Cannon CP, Fonarow GC, Wong ND, Amsterdam E, Hirshfeld JW, Blumenthal RS. A point-by-point response to recent arguments against the use of statins in primary prevention: this statement is endorsed by the American Society for Preventive Cardiology. Clin Cardiol. 2012;35(7):404-9. doi: 10.1002/clc.22016. Epub 2012 Jun 6.
  • Juronen, E., G. Tasa, et al. (2000). Polymorphic glutathione S-transferases as genetic risk factors for senile cortical cataract in Estonians. Invest Ophthalmol Vis Sci 41(8): 2262-7.
  • Kadowaki, T., Hara, K., Kubota, N., Tobe, K., Terauchi, Y., Yamauchi, T., Eto, K., Kadowaki, H., Noda, M., Hagura, R.,and Akanuma, Y. (2002). The role of PPARgamma in high -fat diet-induced obesity and insulin resistance. J Diabetes Complications 16, 41-45.
  • Kahara T, Hayakawa T, Nagai Y, Shimizu A, Takamura T. Gln27Glu polymorphism of the 2 adrenergic receptor gene in healthy Japanese men is associated with the change of fructosamine level caused by exercise. Diabet Res Clin Practice 64: 207-12, 2004.
  • Kahara T, Takamura T, Hayakawa T, Nagai Y, Yamaguchi H, Katsuki T, Katsuki K, Katsuki M, and Kobayashi K. PPARgamma gene polymorphism is associated with exercise-mediated changes of insulin resistance in healthy men. Metabolism 52: 209-212, 2003.
  • Kahleova, R., Palyzova, D., Zvara, K., Zvarova, J., Hrach, K., Novakova, I., Hyanek, J., Bendlova, B., and Kozich, V.(2002). Essential hypertension in adolescents: association with insulin resistance and with metabolism of homocysteine and vitamins. Am J Hypertens 15, 857-864.
  • Kallio P, Kolehmainen M, Laaksonen D, Kekalainen J, Salopuro T, Sivenius K, Pulkkinen L, Mykkanen H, Niskanen L, Uusitupa M, Poutanen K. Dietary carbohydrate modification induces alterations in gene expression in abdominal subcutaneous adipose tissue in persons with the metabolic syndrome: the FUNGENUT study. Am J Clin Nutr 85: 1417-1427, 2007.
  • Kang, J. X. (2004) Achieving balance in the Omega-6/Omega-3 ration trhough nutrigenomics: Fat-1 transgenic mice convert Omega-6 to Omega-3 fatty acids. Simpoulos, A. P., Ordovas, J. M. (eds): Nutrigenetics and Nutrigenomics. World Rev Nutr Diet. Basel, Karger, vol 93, pp 92-98.
  • Kao, W. H., Coresh, J., Shuldiner, A. R., Boerwinkle, E., Bray, M. S., and Brancati, F. L. (2003). Pro12Ala of the peroxisome proliferator-activated receptor-gamma2 gene is associated with lower serum insulin levels in nonobese African Americans: the Atherosclerosis Risk in Communities Study. Diabetes 52, 1568-1572.
  • Karaca S, Cesuroglu T, Kankilic T, Aksoy NH. Allelic frequency of single nucleotide polymorphisms involved in cancer related bioprocesses. Febs J. 2012;279:322-.
  • Karaca S, Cesuroglu T, Kaymaz A. Allelic Frequencies of Genetic Variants Associated with Bone Mineral Density, in Turkish Population. Clin Genet. 2010;78(s1):42.
  • Karaca S, Cesuroglu T, Kocaman E. MALDI-TOF MS Based Genotyping of Single-Nucleotide Variations Predisposing to Cardiovascular Diseases. Clin Genet. 2010;78(s1):57.
  • Karani S, Radha V, Mohan V. Thr54 allele carriers of the Ala54Thr variant of FABP2 gene have associations with metabolic syndrome and hypertriglyceridemia in urban South Indians. Metabolism Clinical and Experimental 55: 1222-12226, 2006.
  • Karen Curtin, Jeannette Bigler, Martha L. Slattery, 2004, “ MTHFR C677T and A1298C Polymorphisms – Diet, Estrogen, and Risk of Colon Cancer”, Cancer Epidemiology Biomarkers & Prevention, 13, 285-292
  • Kawasaki I, Tahara H, Emoto M, Shoji T, Nishizawa Y. Relationship between TaqIB cholesteryl ester transfer protein gene polymorphism and macrovascular complications in Japanese patients with type 2 diabetes. Diabetes. 2002 Mar;51(3):871-4.
  • Kawasaki, I., Tahara, H., Emoto, M., 2002, “Relationship Between TaqIB Cholesteryl Ester Transfer protein gene polymorphism and macrovascular complications in Japanese patients with type 2 diabetes. Diabetes; 51(3):871-4.
  • Keatings, V. M., Cave, S. J., Henry, M. J., Morgan, K., O’Connor, C. M., FitzGerald, M. X., and Kalsheker, N. (2000).A polymorphism in the tumor necrosis factor-alpha gene promoter region may predispose to a poor prognosis in COPD. Chest 118, 971-975.
  • Kekreni, M., Addad, F., Chauffert, M., 2006, “Hyperhomocysteinemia, endothelial nitric oxide synthase polymorphism, and risk of coronary artery disease”, Clin Chem.,52:1, 53-8.
  • Kelly, F., and Sandström, T. (2004). Air pollution, oxidative stress, and allergic response. Lancet 363, 95-96.
  • Kenet, G., Sadetzki, S., Murad, H., 2000, “Factor V Leiden and Antiphospholipid Antibodies Are Significant Risk Factors for Ischemic Stroke in Children”, Stroke, 31, 1283-88.
  • Khaper, N. & Singal, P.K. (2001) Modulation of oxidative stress by a selective inhibition of angiotensin II type 1 receptors in MI rats. J Am Coll Cardiol, 37, 1461-1466.
  • Khoury MJ, Berg A, Coates R, Evans J, Teutsch SM, Bradley LA. The evidence dilemma in genomic medicine. Health affairs. 2008;27(6):1600-11.
  • Khoury MJ, Coates RJ, Evans JP. Evidence-based classification of recommendations on use of genomic tests in clinical practice: Dealing with insufficient evidence. Genet Med. 2010;12(11):680-3.
  • Khoury MJ, Gwinn M, Burke W, Bowen S, Zimmern R. Will genomics widen or help heal the schism between medicine and public health? Am J Prev Med. 2007;33(4):310-7.
  • Khoury MJ, Gwinn ML, Glasgow RE, Kramer BS. A Population Approach to Precision Medicine. Am J Prev Med. 2012;42(6):639-45.
  • Kickbusch I, Payne L. Twenty-first century health promotion: the public health revolution meets the wellness revolution. Health Promot Int. 2003 Dec;18(4):275-8.
  • Kim KS, Owen WL, Williams D, Adams-Campbell LL. A comparison between BMI and Conicity index on predicting coronary heart disease: the Framingham Heart Study. Ann Epidemiol. 2000;10:424-431.
  • Kim, H. S., Newcomb, P. A., Ulrich, C. M., Keener, C. L., Bigler, J., Farin, F. M., Bostick, R. M., and Potter, J. D. (2001). Vitamin D receptor polymorphism and the risk of colorectal adenomas: evidence of interaction with dietary vitamin D and calcium. Cancer Epidemiol Biomarkers Prev 10, 869-874.
  • Kim, J. W., C. G. Lee, et al. (2000). Combined analysis of germline polymorphisms of p53, GSTM1, GSTT1,CYP1A1, and CYP2E1: relation to the incidence rate of cervical carcinoma.” Cancer 88(9): 2082-91.
  • Kimura, K., Y. Isashiki, et al. (2000). Genetic association of manganese superoxide dismutase with exudative age-related macular degeneration. Am J Ophthalmol 130(6): 769-73.
  • Klein-Ritter D. An evidence-based review of the AMA/AHA guideline for the primary prevention of ischemic stroke. Geriatrics. 2009 Sep;64(9):16-20, 28.
  • Klerk, M., Lievers, K.J.A., Kluijtmans, L.A.J., 2003, “The 2576 A>G variant in the gene encoding methionine synthase: its relation with plasma homocysteine levels and risk of coronary heart disease in a Dutch case control study”, Thromb Res, 110, 87-91.
  • Kluijtmans, L.A.J., Young, I.S., Boreham, C.A., 2003, “Genetic and nutritional factors contributing to hyperhomocysteinemia in young adults”, Blood, 101:7, 2483-8.
  • Knoblauch, H., Busjahn, A., Muller, M.B., 2000, “Peroxisome proliferator-activated receptor gene locus is related to body mass index and lipid values in healthy nonobese subjects “, Arterioscler Thrombos Vasc Biol, 19:12, 2940-44.
  • Kobashi, G., Hata, A., Shido, K., 2005, “Insertion/deletion polymorphism of the angiotensin-converting enzyme gene and preeclampsia in Japanese patients”, Semin Thromb Hemost, 31:3, 346-50
  • Koh, W.P., Yuan, J.M., Sun, C.L., 2003, “Angiotensin I-Converting Enzyme (ACE) Gene Polymorphism and Breast Cancer Risk among Chinese Women in Singapore”, Cancer Res, 63, 573-8.
  • Komitopoulou, A., Platokouki, P., Kapsimali, Z., 2006, “Mutations and Polymorphisms in Genes Affecting Hemostasis Proteins and Homocysteine Metabolism in Children with Arterial Ischemic Stroke”, Cerebrovasc Dis, 22:1, 13-20.
  • Kote-Jarai, Z., D. Easton, et al. (2001). Relationship between glutathione S-transferase M1, P1 and T1 polymorphisms and early onset prostate cancer. Pharmacogenetics 11(4): 325-30.
  • Kovalevsky, G., Gracia, C.R., Berlin, J.A., 2004, “Evaluation of the Association Between Hereditary Thrombophilias and Recurrent Pregnancy Loss”, Arch Intern Med, 164:5, 558-63.
  • Kowa, H., Fusayasu, E., Ijiri, T., 2005, “Association of the insertion/deletion polymorphism of the angiotensin I-converting enzyme gene in patients of migraine with aura.” Neurosci Lett, 374(2):129-31.
  • Kölsch, H., Jessen, F., Freymann, N., 2005, “ACE I/D polymorphism is a risk factor of Alzheimer’s disease but not of vascular dementia”, Neurosci Lett, 377, 37-9.
  • Kruger, W. D., Evans, A. A., Wang, L., Malinow, M. R., Duell, P. B., Anderson, P. H., Block, P. C., Hess, D. L., Graf, E.E., and Upson, B. (2000). Polymorphisms in the CBS gene associated with decreased risk of coronary artery disease and increased responsiveness to total homocysteine lowering by folic acid. Mol Genet Metab 70,53-60.
  • Kumar, J., Das, S.K., Sharma, P., 2005, “Homocysteine levels are associated with MTHFR A1298C polymorphism in Indian population”, J Hum Genet, 50, 655-663.
  • Kurokawa N, Nakai K, Kameo S, Liu ZM, and Satoh H. Association of BMI with the beta3-adrenergic receptor gene polymorphism in Japanese: meta-analysis. Obes Res 9: 741-745, 2001.
  • L, Brunzell JD, Goldberg AC, Goldberg IJ, Sacks F, Murad MH, Stalenhoef AF. Evaluation and treatment of hypertriglyceridemia: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2012 Sep;97(9):2969-89.
  • Lamblin, N., Bauters, C., Helbecque, N., 2001, “Gene polymorphisms of pro- (or anti-) inflammatory cytokines and vascular disease”, Eur Heart J, 22, 2219-2220.
  • Lampe, J. W.; Chen, C., et. al., Modulation of human glutathione S-transferases by botanically defined vegetable diets. Cancer Epidemiol Biomarkers Prev 2000 Aug;9(8):787-93.
  • Lanas, A., Garcia, G.M.A., Santolaria, S., 2001, “TNF and LTA gene polymorphismsreveal different risk in gastric and düodenal ulcer patients”, Genes Immun, 2.8, 415-21
  • Landi, S. (2000). Mammalian class theta GST and differential susceptibility to carcinogens: a review. Mutat Res 463(3): 247-83.
  • Landmesser, U., Merten, R., Spiekermann, S., Buttner, K., Drexler, H. & Hornig, B. (2000) Vascular extracellularsuperoxide dismutase activity in patients with coronary artery disease: relation to endothelium-dependent vasodilation. Circulation, 101, 2264-2270.
  • Lane, D.A., Grant, P.J., 2000, “Role of hemostatic gene polymorphisms in venous and arterial thrombotic disease”, Blood, 95:5, 1517-32
  • Langdahl, B.L., Gravholt, C.L., Brixen, K., 2000, “Polymorphisms in the vitamin D receptor gene and bone mass, bone turnover and osteoporotic fractures”, Eur J Clin Invest, 30:7, 608-17.
  • Lange LA, Norris JM, Langefeld CD, Nicklas BJ, Wagenknecht LE, Saad MF, and Bowden DW. Association of adipose tissue deposition and beta-2 adrenergic receptor variants: the IRAS family study. Int J Obes (Lond) 29: 449-457, 2005.
  • Laukkanen, M.O., Lehtolainen, P., Turunen, P., Aittomaki, S., Oikari, P., Marklund, S.L. & Yla-Herttuala, S. (2000)Rabbit extracellular superoxide dismutase: expression and effect on LDL oxidation. Gene, 254, 173-179.
  • Lee Hood. Nat Biotech. 2011;29(3):191-.
  • Lee, C.N., Su, Y.N., Cheng, W.F., 2005, “Association of the C677T MTHFR mutation with congenital heart diseases”, 84, 1134-40.
  • Lee, J. M., Y. C. Lee, et al. (2000). Genetic polymorphisms of p53 and GSTP1,but not NAT2,are associated with susceptibility to squamous-cell carcinoma of the esophagus. Int J Cancer 89(5): 458-64.
  • Lehmann, D.J., Borja, M.C., Warden, D.R., 2005, “Large Meta-Analysis Establishes the ACE Insertion-Deletion Polymorphism as a Marker of Alzheimer’s Disease”, Am J Epidemiol, 162:4, 305-17.
  • Lenz, H-J., Ingles, S. A, et al (2002) The -9Ala/-9Val polymorphism in the mitochondrial targeting sequence of the manganese superoxide dismutase gene (MnSOD) is associated with age among Hispanics with colorectal carcinoma. Oncology reports 9(2):235-38.
  • Li D, Ahmed M, Li Y, “5,10-Methylenetetrahydrofolate reductase polymorphisms and the risk of pancreatic cancer”,Cancer Epidemiol Biomarkers Prev, 14.6,1470-6
  • Li, S., Chen, W., Srinivasan, S. R., Boerwinkle, E., and Berenson, G. S. (2003). The peroxisome proliferatoractivated receptor-gamma2 gene polymorphism (Pro12Ala) beneficially influences insulin resistance and its tracking from childhood to adulthood: the Bogalusa Heart Study. Diabetes 52, 1265-1269.
  • Lichy, C., Si, T.D., Reuner, K., 2006, “Risk of cerebral venous thrombosis and novel gene polymorphisms of the coagulation and fibrinolytic systems”, J Neurol, 253, 316-20.
  • Lim LS, Haq N, Mahmood S, Hoeksema L, ACPM Prevention Practice Committee, American College of Preventive Medicine. Atherosclerotic cardiovascular disease screening in adults: American College of Preventive Medicine position statement on preventive practice. Am J Prev Med 2011 Mar;40(3):381.e1-10.
  • Lin, H.J., Zhou, H., et al. Glutathione transferase GSTT1, broccoli, and prevalence of colorectal adenomas. Pharmacogenetics 12:175-179.
  • Lindi VI, Uusitupa MI, Lindstrom J, Louheranta A, Eriksson JG, Valle TT, Hamalainen H, Ilanne-Parikka P, Keinanen-Kiukaanniemi S, Laakso M, and Tuomilehto J. Association of the Pro12Ala polymorphism in the PPAR-gamma2 gene with 3-year incidence of type 2 diabetes and body weight change in the Finnish Diabetes Prevention Study. Diabetes 51: 2581-2586, 2002.
  • Lio, D., Annoni, G., Licastro, F., 2006, “TNF- -308 G/A polymorphism is associated with age at onset of Alzheimer’s disease”, Mech Ageing Develop; 127(6):567-71.
  • Liu JH, Zingmond D, Etzioni DA, O’Connell JB, Maggard MA, Livingston EH, et al. Characterizing the performance and outcomes of obesity surgery in California. Am Surg. 2003;69:823-8.
  • Liu, H.K., Li, X.F., Zhang, S.Z., 2005, “Association of SstI polymorphism in APOC3 gene with hyperglyceridaemia in coronary atherosclerotic heart disease and type 2 diabetes mellitus in Chinese population”, Yi Chuan Xue Bao, 32:1, 11-18.
  • Liu, J., Zhao, D., Liu, S., 2003, “Study on the distribution and association of cholesteryl ester transfer protein- TaqIB polymorphism and plasma concentration in general population”, Zhonghua Liu Xing Bing Xue Za Zhi, 24:4, 300-3.
  • Liu, S., Song, Y., Hu, F.B., 2004, “A prospective study of the APOA1 XmnI and APOC3 SstI polymorphisms in the APOA1/C3/A4 gene cluster and risk of incident myocardial infarction in men”, Atherosclerosis, 177, 119-26.
  • Liu, Y., Schaad, Y.B., Fallin, M.D., 2006, “IL-6 haplotypes , inflammation and risk for cardiovascular disease in multiethnic dialysis cohort”, Clin J Am Soc Nephrol, 1, 281-7.
  • Liu, Y.Z., Liu, Y.J., Recker, R.R., 2003, “Molecular studies of identification of genes for osteoporosis: the 2002 update. J Endocrinol;177(2):147-96.
  • Lloyd-Jones DM. Cardiovascular risk prediction: basic concepts, current status, and future directions. Circulation. 2010 Apr 20;121(15):1768-77.
  • Loebstein R, Yonath H, Peleg D, Almog S, Rotenberg M, Lubetsky A, Roitelman J, Harats D, Halkin H, Ezra D. Interindividual variability in sensitivity to warfarin–Nature or nurture? Clin Pharmacol Ther. 2001 Aug;70(2):159- 64.
  • London, S. J., J. M. Yuan, et al. (2000). Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms,and lung-cancer risk: a prospective study of men in Shanghai, China. Lancet 356(9231): 724-9.
  • Loos RJF, Bouchard C. Obesity – is it a genetic disorder? Journal of Internal Medicine 2003; 254: 401–425.
  • Lorentzon, M., Lorentzon, R., and Nordstrom, P. (2000). Interleukin-6 gene polymorphism is related to bone mineral density during and after puberty in healthy white males: a cross-sectional and longitudinal study. J Bone Miner Res 15, 1944-1949.
  • Lorentzon, M., Lorentzon, R., and Nordstrom, P. (2001). Vitamin D receptor gene polymorphism is related to bone density, circulating osteocalcin, and parathyroid hormone in healthy adolescent girls. J Bone Miner Metab 19, 302-307.
  • Louis, E., Peeters, M., Franchimont, D., Seidel, L., Fontaine, F., Demolin, G., Croes, F., Dupont, P., Davin, L., Omri, S., et al. (2000). Tumour necrosis factor (TNF) gene polymorphism in Crohn’s disease (CD): influence on disease behaviour? Clin Exp Immunol 119, 64-68.
  • Loukides G, Gkoulalas-Divanis A, Malin B. Anonymization of electronic medical records for validating genome-wide association studies. P Natl Acad Sci USA. 2010;107(17):7898-903.
  • Lu, W., Pan, K., Zhang, L., “Genetic polymorphisms of interleukin (IL) 1B, IL-IRN, IL-8, IL-10, and tumor necrosis factor alpha and risk of gastric cancer in a Chinese population”, Carcinogenesis, 26:3, 631-6.
  • Lunetta KL, D’Agostino RB Sr, Karasik D, Benjamin EJ, Guo CY, Govindaraju R, Kiel DP, Kelly-Hayes M, Massaro JM, Pencina MJ, Seshadri S, Murabito JM. Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. BMC Med Genet. 2007 Sep 19;8 Suppl 1:S13.
  • Lv Q, Lu J, Wu W, Sun H, Zhang J. Association of the methylenetetrahydrofolate reductase gene A1298C polymorphism with stroke risk based on a meta-analysis. Genet Mol Res. 2013 Dec 19;12(4):6882-94.
  • Lyon HN, Hirschhorn JN. Genetics of common forms of obesity: a brief overview. American Journal of Clinical Nutrition 2005; 82(1 Suppl):215S–217S.
  • Lyssenko V, Jonsson A, Almgren P, Pulizzi N, Isomaa B, Tuomi T, et al. Clinical risk factors, DNA variants, and the development of type 2 diabetes. N Engl J Med. 2008;359(21):2220-32.
  • MacDonald, H. M., McGuigan, F. A., New, S. A., Campbell, M. K., Golden, M. H., Ralston, S. H., and Reid, D. M. (2001). COL1A1 Sp1 polymorphism predicts perimenopausal and early postmenopausal spinal bone loss. J Bone Miner Res 16, 1634-1641.
  • Macho-Azcarate T, Calabuig J, Marti A, Martinez JA. A maximal effort trial in obese women carrying the beta2- adrenoceptor Gln27Glu polymorphism. J Physiol Biochem. 2002 Jun;58(2):103-8.
  • Macho-Azcarate T, Marti A, Calabuig J, Martinez JA. Basal fat oxidation and after a peak oxygen consumption test in obese women with a beta2 adrenoceptor gene polymorphism. J Nutr Biochem. 2003 May;14(5):275-9.
  • Macho-Azcarate T, Marti A, Gonzalez A, Martinez JA, Ibanez J. Gln27Glu polymorphism in the beta2 adrenergic receptor gene and lipid metabolism during exercise in obese women. Int J Obes Relat Metab Disord. 2002 Nov;26(11):1434-41.
  • Macho-Azcarate T, Marti A, Gonzalez A, Martinez JA, Ibanez J. Gln27Glu polymorphism in the beta2 adrenergic receptor gene and lipid metabolism during exercise in obese women. Int J Obesity 26: 1434-41, 2002.
  • Mammes O, Aubert R, Betoulle D, Pean F, Herbeth B, Visvikis S, Siest G, Fumeron F. LEPR gene polymorphisms: associations with overweight, fat mass and response to diet in women. Eur J Clin Invest. 2001 May;31(5):398-404.
  • Mann, C. L., M. B. Davies, et al. (2000) Glutathione S-transferase polymorphisms in MS: their relationship to disability. Neurology 54(3): 552-7.
  • Mann, V., Hobson, E. E., Li, B., Stewart, T. L., Grant, S. F., Robins, S. P., Aspden, R. M., and Ralston, S. H. (2001). ACOL1A1 Sp1 binding site polymorphism predisposes to osteoporotic fracture by affecting bone density and quality. J Clin Invest 107, 899-907.
  • Mann, V., Ralston, S.H., 2003, “Meta-analysis of COL1A1 Sp1 polymorphism in relation to bone mineral density and osteoporotic fracture”, Bone, 32:6, 711-7.
  • Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, et al. Finding the missing heritability of complex diseases. Nature. 2009;461(7265):747-53.
  • Manolio TA, Green ED. Genomics reaches the clinic: from basic discoveries to clinical impact. Cell. 2011;147(1):14-6.
  • Mar, R., Pajukanta, P., Allayee, H., 2006, “Association of the apolipoprotein A1/C3/A4/A5 gene cluster with triglyceride levels and LDL particle size in familial combined hyperlipidemia”, Circ Res, 94, 993-9.
  • Mariman EC. Nutrigenomics and nutrigenetics: the ‘omics’ revolution in nutritional science. Biotechnol Appl Biochem 2006; 44 (Pt 3):119-28.
  • Marklund, S.L. (1984) Extracellular superoxide dismutase in human tissues and human cell lines. J Clin Invest, 74, 1398-1403.
  • Marteau TM, French DP, Griffin SJ, Prevost AT, Sutton S, Watkinson C, et al. Effects of communicating DNA-based disease risk estimates on risk-reducing behaviours. Cochrane Database Syst Rev. 2010(10):CD007275.
  • Marteau, J.B., Zaiou, M., Siest, G., Visvikis-Siest, S. (2005) Genetic determinants of blood pressure regulation. J Hypertens; 23(12):2127-43.
    Marti A, Corbalan MS, Martinez-Gonzalez MA, and Martinez JA. TRP64ARG polymorphism of the beta 3- adrenergic receptor gene and obesity risk: effect modification by a sedentary lifestyle. Diabetes Obes Metab 4: 428-430, 2002.
  • Marti A, Corbalan MS, Martinez-Gonzalez MA. CHO intake alters obesity risk associated with Pro12Ala polymorphism of PPARG gene. J. Physiol. Biochem., 58(4): 219-220,2002.
  • Martin GM, Bergman A, Barzilai N. Genetic Determinants of Human Health Span and Life Span: Progress and New Opportunities. PLoS Genet. 2007 July; 3(7): e125.
  • Martinez de Villarreal, L. E., Delgado-Enciso, I., Valdez-Leal, R., Ortiz-Lopez, R., Rojas-Martinez, A., Limon- Benavides, C., Sanchez-Pena, M. A., Ancer-Rodriguez, J., Barrera-Saldana, H. A., and Villarreal-Perez, J. Z.(2001). Folate levels and N(5),N(10)-methylenetetrahydrofolate reductase genotype (MTHFR) in mothers of offspring with neural tube defects: a case-control study. Arch Med Res 32, 277-282.
  • Martinez JA, Corbalan MS, Sanchez-Villegas A, Forga L, Marti A, and Martinez-Gonzalez MA. Obesity risk is associated with carbohydrate intake in women carrying the Gln27Glu beta2-adrenoceptor polymorphism. J Nutr 133: 2549-2554, 2003.
  • Martinez JA, Corbalan MS, Sanchez-Villegas A, Forga L, Marti A, Martinez-Gonzalez MA. Obesity risk is associated with carbohydrate intake in women carrying the Gln27Glu beta2-adrenoceptor polymorphism. J Nutr. 2003 Aug;133(8):2549-54.
  • Mason, L. F., McNeill, G., Avenell, A. (2003). Genetic variation and the lipid response to dietary intervention: a systematic review. Am J Clin Nutr 77:1098–111.
  • Masugi J, Tamori Y, Mori H, Koike T, and Kasuga M. Inhibitory effect of a proline-to-alanine substitution at codon 12 of peroxisome proliferator-activated receptor-gamma 2 on thiazolidinedione-induced adipogenesis. Biochem Biophys Res Commun 268: 178-182, 2000.
  • Masuo K, Katsuya T, Fu Y, Rakugi H, Ogihara T, and Tuck ML. Beta2- and beta3-adrenergic receptor polymorphisms are related to the onset of weight gain and blood pressure elevation over 5 years. Circulation 111: 3429-3434, 2005.
  • Masuo K, Katsuya T, Kawaguchi H, Fu Y, Rakuga H, et al. B2-adrenoreceptor polymorphisms relate to obesity through blunted leptin-mediated sympathetic activation. Am J Hypertens, 19: 1084-91, 2006.
  • Matsui, A., T. Ikeda, et al. (2000) Increased formation of oxidative DNA damage, 8-hydroxy-2′-deoxyguanosine, in human breast cancer tissue and its relationship to GSTP1 and COMT genotypes. Cancer Lett 151(1): 87-95.
  • Matsuo, K., Hamajima, N., Hirai, T., 2002, “Methionine Synthase Reductase Gene A66G Polymorphism is Associated with Risk of Colorectal Cancer”, Asian Pac J Canc Prev, 3:4, 354-9
  • McCarthy MI. Genomics, type 2 diabetes, and obesity. N Engl J Med. 2010;363(24):2339-50.
  • McDermott U, Downing JR, Stratton MR. Genomics and the continuum of cancer care. N Engl J Med. 2011;364(4):340-50.
  • McGuigan, F.E.A., Reid, D.M., Ralston, S.H., 2000, “Susceptibility to Osteoporotic Fracture is Determined by Allelic Variation at the Sp1 Site, Rather than Other Polymorphic Sites at the COL1A1 Locus”, Osteoporos Int, 11, 338-43
  • McKean-Cowdin R, Li X, Bernstein L, McTiernan A, Ballard-Barbash R, Gauderman WJ, and Gilliland F. The ADRB3 Trp64Arg variant and obesity in African-American breast cancer cases. Int J Obes 31: 1110-1118, 2008.
  • McNulty H, McKinley MC, Wilson B, 2002,”Impaired functioning of thermolabile methylenetetrahydrofolate reductase is dependent on riboflavin status: implications for riboflavin requirements.”
  • McNulty H, Pentieva K, Hoey L, Ward M. Homocysteine, B-vitamins and CVD. Proc Nutr Soc. 2008 May;67(2):232-7.
  • McTigue K, Harris R, Hemphill MB, Bunton AJ, Lux LJ, Sutton S, Lohr KN, et al. Screening and Interventions for Overweight and Obesity in Adults. Systematic Evidence Review No. 21. Prepared by Research Triangle Institute, NC, under contract no. 290-97-0011. Technical Support of the U.S. Preventive Services Task Force. Rockville, MD: Agency for Healthcare Research and Quality & U.S. Department of Health and Human Services; December 2003.
  • Medica I, Kastrin A, Peterlin B. Genetic polymorphisms in vasoactive genes and preeclampsia: a meta-analysis. Eur J Obstet Gynecol Reprod Biol. 2007 Apr;131(2):115-26.
  • Meirhaeghe, A., Amouyel, P., 2004, “Impact of genetic variation of PPARgamma in humans”, Mol Genet Metabol, 83, 93-102.
  • Mellbin LG, Anselmino M, Rydén L. Diabetes, prediabetes and cardiovascular risk. Eur J Cardiovasc Prev Rehabil. 2010 May;17 Suppl 1:S9-14.
  • Mello, G., Parretti, E., Marozio, L., 2005, “Thrombophilia Is Significantly Associated With Severe Preeclampsia”, Hypertension, 46, 1252-53.
  • Memisoglu A, Hu PJ, Hankinson SE, Manson JE, De Vivo I, Willet WC, and Hunter DJ. Interaction between a peroxisome proliferatoractivated receptor gamma gene polymorphism and dietary fat intake in relation to body mass. Hum Mole Genet 12: 2923-2929, 2001.
  • Mendonca, I., Freitas, I.A., Sousa, C.A., 2004, “Angiotensin converting enzyme gene polymorphisms and coronary risk in a Portuguese population”, Rev Port Cardiol, 23:12, 1593-601.
  • Menopause and osteoporosis update 2009. J Obstet Gynaecol Can 2009 Jan;31(1 Suppl 1) :S11-8.
  • Metcalfe S, Hurworth R, Newstead J, Robins R. Needs assessment study of genetics education for general practitioners in Australia. Genet Med 2002;4:71–77.
  • Methot, J., Hamelin, B.A., Bogaty, P., 2005, “ACE-DD genotype is associated with the occurrence of acute coronary syndrome in postmenopausal women”, Int J Cardiol, 105, 308-14.
  • Mezquita, R.P., Munoz, M.T., Luna, J.D., 2002, “Performance of COLIA1 Polymorphism and Bone Turnover Markers to Identify Postmenopausal Women with Prevalent Vertebral Fractures”, Osteoporos Int, 13, 506-12.
  • Miles, J.S., Miletich, J.P., Goldhaber, S.Z., 2001, “G20210A mutation in the prothrombin gene and the risk of recurrent venous thromboembolism “, J Am Coll Cardiol, 37, 215-8.
  • Millikan, R.C., Player, J., Cotret, A.R., 2004, “MnSOD Ala-9Val polymorphism and risk of breast cancer in a population based case-control study of African Americans and whites”, Breast Can Res, 6, 264-274.
  • Mitra, S., Desai, M., Khatkhatay, M.I., 2006, “Vitamin D receptor gene polymorphisms and bone mineral density in postmenopausal Indian women”, Maturitas, 55(1):27-35.
  • Mitrunen, K., N. Jourenkova, et al. (2001) Glutathione S-transferase M1, M3, P1, and T1 genetic polymorphisms and susceptibility to breast cancer. Cancer Epidemiol Biomarkers Prev 10(3): 229-36.
  • Mitrunen, K., Sillanpaa, P., Kataja, V., 2001, “Association between MnSOD gene polymorphism and breast cancer risk”, Carcinogenesis, 22:5, 827-9.
  • Moffat, M.F., Cookson, W.O.C.M., “Tumor necrosis factor haplotypes and asthma”, Hum Mol Genet, 6:4, 551-4.
  • Mogilnicka, E.N., Adamaek, L., Grzanka, P., 2003, “Genetic polymorphisms associated with acute pulmonaryembolism and deep venous thrombosis”, Eur Respir J, 21, 25-30.
  • Mohllajee, A.P., Curtis, K.M., Martins, S.L., Peterson, H.B., 2005, “Does use of hormonal contraceptives among women with thrombogenic mutations increase their risk of venous thromboembolism? A systematic review”, Contraception, 73(2):166-78.
  • Mori, H., Ikegami, H., Kawaguchi, Y., 2001, “The Pro12 Ala substitution in PPAR- is associated with resistance to development of diabetes in the general population: Possible involvement in impairment of insulin secretion in individuals with type 2 diabetes”, Diabetes, 50:4, 891-4.
  • Morimitsu, Y., Nakagawa, Y., et al. (2002) A sulforaphane analogue that potently activates the Nrf2-dependent detoxification pathway. J. Biol. Chem. 277(5):3456-63.
  • Moriyama, M., Okamura, P., Kajinami, K., 2002, “Effects of serum B vitamins on elevated plasma homocysteine levels associated with the mutation of MTHFR gene in Japanese”, Atherosclerosis, 164, 321-8. • Morley AA. The somatic mutation theory of ageing. Mutat Res. 1995 Oct;338(1-6):19-23.
  • Morrison, A.C., Ballantyne, C.M., Bray, M., 2002, “LPL Polymorphism Predicts Stroke Risk in Men”, Genet Epidemiol, 22, 233-42.
  • Mosca L, Benjamin EJ, Berra K, Bezanson JL, Dolor RJ, Lloyd-Jones DM, Newby LK, Pina IL, Roger VL, Shaw LJ, Zhao D, Beckie TM, Bushnell C, D’Armiento J, Kris-Etherton PM, Fang J, Ganiats TG, Gomes AS, Gracia CR, Haan CK, Jackson EA, Judelson DR, Kelepouris E, Lavie CJ, Moore A, Nussmeier NA, Ofili E, Oparil S, Ouyang P, Pinn VW, Sherif K, Smith SC Jr, Sopko G, Chandra-Strobos N, Urbina EM, Vaccarino V, Wenger NK. Effectiveness-based guidelines for the prevention of cardiovascular disease in women–2011 update: a guideline from the American Heart Association. Circulation 2011 Mar 22;123(11):1243-62.
  • Moskalenko, M.V., Aseev, M.V., Zazerskaia, I.E., 2002, “Analysis of association of Col1a1 gene alleles with the development of osteoporosis”, Genetika, 38:12, 1699-703.
  • Motohashy, Y., Maruyama, T., Murata, M., 2004, “Role of genetic factors (CETP gene Taq I B polymorphism and Apo A-I gene Msp I polymorphism) in serum HDL-C levels in women”, Nutr Metab Cardiovasc Dis, 14:1, 6- 14.
  • Mozaffarian D, Ludwig DS. Dietary guidelines in the 21st century–a time for food. Jama. 2010;304(6):681-2.
  • Mtiraoui, N., Zammiti, W., Ghazouani, L., 2006, “MTHFR C677T and A1298C polymorphism and changes in homocysteine concentrations in women with idiopathic recurrent pregnancy losses”, Reproduction, 131:2, 395- 401.
  • Mudway, I. S., and K elly, F. J. (2000). Ozone and the lung: a sensitive issue. Mol Aspects Med 21, 1-48.
  • Munday, R. & Munday, C.M. (2001) Relative activities of organosulfur compounds derived from onions and garlic in increasing tissue activities of quinone reductase and glutathione transferase in rat tissues. Nutr Cancer, 40, 205-210.
  • Murphy S, Churchill S, Bry L, Chueh H, Weiss S, Lazarus R, et al. Instrumenting the health care enterprise for discovery research in the genomic era. Genome Res. 2009;19(9):1675-81.
  • Murtagh MJ, Demir I, Harris JR, Burton PR. Realizing the promise of population biobanks: a new model for translation. Human Genetics. 2011;130(3):333-45.
  • Mutch DM, Wahli W, Williamson G. Nutrigenomics and nutrigenetics: the emerging faces of nutrition. The FASEB Journal 2005; Vol. 19 p 1602-1616.
  • Myllykangas, L., Polvikoski, P., Sulkava, R., 2001, “Association of lipoprotein lipase Ser447Ter polymorphism with brain infarction: a population-based neuropathological study”, Ann Med, 33:7, 486-92.
  • Nagase, S., Suzuki, H., Wang, Y., 2003, “Association of ecNOS gene polymorphisms with end stage renal diseases”, Mol Cell Biochem, 244, 113-8.
  •  Nakanishi, Y.S., Urabe, T., Hattori, N., 2001, “Polymorphism of the Lipoprotein Lipase Gene and Risk of Atherothrombotic Cerebral Infarction in the Japanese”, Stroke, 32, 1481-6.
  • Nassr, M.A., Attas, O.A., Patel, A., 2003, “Association between the cholesteryl ester transfer protein TaqI-detectable B polymorphism and low high-density lipoprotein cholesterol concentration in Saudis”, Clin Sci, 105, 467-72.
  • National Academy of Clinical Biochemistry (NACB). Emerging biomarkers for primary prevention of cardiovascular disease and stroke. Washington (DC): National Academy of Clinical Biochemistry; 2009. 70 p.
  • National Collaborating Center for Chronic Conditions/National Institute for Health and Clinical Excellence (NCCCC/NICE). Type 2 diabetes. The management of type 2 diabetes. London (UK): National Institute for Health and Clinical Excellence (NICE); 2009 May. 49 p.
  • National Collaborating Centre for Chronic Conditions. Type 2 diabetes. The management of type 2 diabetes. London (UK): National Institute for Health and Clinical Excellence (NICE); 2009 May. 49 p. (Clinical guideline; no. 87).
  • National Collaborating Centre for Primary Care. Lipid modification. Cardiovascular risk assessment and the modification of blood lipids for the primary and secondary prevention of cardiovascular disease. London (UK): National Institute for Health and Clinical Excellence (NICE); 2008 May. 37 p. (Clinical guideline; no. 67).
  • National Office of Public Health Genomics, Centers for Disease Control and Prevention (CDC). Obesity and Genetics: A Public Health Perspective. Public Health Perspective Series June 2006.
  • Nazar, V.S., Vaughan, T.L., Stapleton, P., 2003, “A population-based study of glutathione S-transferase M1, T1 and P1 genotypes and risk for lung cancer”, Lung Canc, 40, 247-58.
  • Nazki FH, Sameer AS, Ganaie BA. Folate: metabolism, genes, polymorphisms and the associated diseases. Gene. 2014 Jan 1;533(1):11-20. doi: 10.1016/j.gene.2013.09.063. Epub 2013.
  • Nelson SE. Management of patients with type 2 diabetes. Curr Med Res Opin. 2011 Oct;27(10):1931-47.
  • Ng, D.P.G., Tai, B.C., Koh, D., 2005, “Angiotensin-I converting enzyme insertion/deletion polymorphism and its association with diabetic nephropathy: a meta-analysis of studies reported between 1994 and 2004 and comprising 14727 subjects”, Diabetologia, 48, 1008-16.
  • NHLBI Working Group on Competencies for Overweight and Obesity Identification, Prevention, and Treatment. Working Group Report on Competencies for Overweight and Obesity Identification, Prevention, and Treatment. May 3-4, 2005. 6701 Rockledge Drive, Bethesda, MD 20892.
  • Nicaud, V., Raoux, S., Poirier, O., Cambien, F., O’Reilly, D. S., and Tiret, L. (2002). The TNF alpha/G-308A polymorphism influences insulin sensitivity in offspring of patients with coronary heart disease: the European Atherosclerosis Research Study II. Atherosclerosis 161, 317-325.
  • Nishimura, M., Matsuoka, M., Maeda, M., Mizuta, I., Mita, S., Uchino, M., Matsui, M., Kuroda, Y., Kawakami, H., Kaji, R., et al. (2002). Association between interleukin-6 gene polymorphism and human T-cell leukemia virus type I associated myelopathy. Hum Immunol 63, 696-700.
  • Niu, T., and Xu, X. (2001). Candidate genes for osteoporosis. Therapeutic implications. Am J Pharmacogenomics 1, 11-19.
  • Noble D, Mathur R, Dent T, Meads C, Greenhalgh T., Risk models and scores for type 2 diabetes: systematic review. BMJ 2011;343.
  • Noiri, E., Satoh, H., Taguchi, J., 2002, “Association of eNOS Glu298Asp Polymorphism With End-Stage Renal Disease”, Hypertension, 40, 535-40 of the Endothelial Nitric Oxide Synthase Gene With Severe Preeclampsia”, J Soc Gynecol Invest, 7, 238-41.
  • Noone, E., Roche, H.M., Black, I., 2000, “Effect of postprandial lipaemia and Taq 1B polymorphism of the cholesteryl ester transfer protein (CETP) gene on CETP mass, activity, associated lipoproteins and plasma lipids”, Br J Nutr, 84, 203-9.
  • Norheim, O. F., Gjelsvik, B. r., Klemsdal, T. O., Madsen, S., Meland, E., Narvesen, S., et al. (2011). Norway’s new principles for primary prevention of cardiovascular disease: age differentiated risk thresholds. BMJ, 343.
  • Norppa, H., 2001, “Genetic polymorphisms and chromosome damage”, Int J Hyg Environ Health, 204:1, 31-8.
  • Nutrition recommendations and interventions for diabetes: a position statement of the American Diabetes Association. Diabetes Care 2008 Jan;31 Suppl 1:S61-78.
  • O’Keefe, G.E., Hybki, D.L., Munford, R.S., 2002, “The G>A single nucleotide polymorphism at the -308 position in the TNF- promoter increases the risk for severe sepsis after trauma”, J Trauma, 52:5, 817-25.
  • O’Leary, V.B., McDermott, A.P., Molloy, A.M., 2002, “MTRR and MTHFR Polymorphism: Link to Down Syndrome?”, Am J Med Genet, 107, 151-5.
  • Oh, J. Y., and Barrett-Connor, E. (2002). Association between vitamin D receptor polymorphism and type 2 diabetes or metabolic syndrome in community-dwelling older adults: the Rancho Bernardo Study.Metabolism 51, 356-359.
  • Ohishi, M., Rakugi, H., Miki, T., Katsuya, T., Okamura, A., Kamide, K., Nakata, Y., Takami, S., Ikegami, H.,Yanagitani, Y., et al. (2000). Deletion polymorphism of angiotensin-converting enzyme gene is associated with postprandial hyperglycaemia in individuals undergoing general check-up. Clin Exp Pharmacol Physiol 27, 483-487.
  •  O’Keefe, G. E., Hybki, D. L., and Munford, R. S. (2002). The G–>A single nucleotide polymorphism at the -308 position in the tumor necrosis factor-alpha promoter increases the risk for severe sepsis after trauma. J Trauma 52, 817-825; discussion 825-816.
  • Olivieri, O., Bassi, A., Straniery, C., 2003, “Apolipoprotein C-III, metabolic syndrome and risk of cronary artery disease”, J Lipid Res, 44, 2374-81.
  • Omran AB. The epidemiological transition. A theory of the epidemiology of population change. Milbank Q 1971;49:509-37.
  • oodside JV, McCall D, McGartland C, Young IS. Micronutrients: dietary intake v. supplement use. P Nutr Soc. 2005;64(4):543-53.
  • Ordovas JM, Corella D, Cupples LA, Demissie S, Kelleher A, Coltell O, Wilson PW, Schaefer EJ, Tucker K. Polyunsaturated fatty acids modulate the effects of the APOA1 G-A polymorphism on HDL-cholesterol concentrations in a sex-specific manner: the Framingham Study. Am J Clin Nutr. 2002 Jan;75(1):38-46.
  • Ordovas JM, Litwack-Klein L, Wilson PW, Schaefer MM, Schaefer EJ. (1987) Apolipoprotein E isoform phenotyping methodology and population frequency with identification of apoE1 and apoE5 isoforms. J Lipid Res. 28(4): 371-80.
  • Ordovas JM. Genetic interactions with diet influence the risk of cardiovascular disease. Am J Clin Nutr 2006; 83(2):443S-446S.
  •  Ordovas, J. M., Corella, D. (2004). Genes, Diet and Plasma Lipids: The evidence from observational studies. Simpoulos A. P., Ordovas J.M. (eds): Nutrigenetics and Nutrigenomics. World Rev Nutr Diet. Basel, Karger, vol 93, pp 41-76.
  • Ordovas, JM., Corella, D., Demissie, S., Cupples, A., Couture, P. Coltell, O., Wilson, P., Scharfer, E., Tucker, K.L. (2002). Dietary Fat Intake Determines the Effect of a Common Polymorphism in the Hepatic Lipase Gene Version 1.24, 16 Jan 2004, Sciona Ltd, Confidential 44.
  • Ortlepp, J. R., Lauscher, J., Hoffmann, R., Hanrath, P., and Joost, H. G. (2001). The vitamin D receptor gene variant is associated with the prevalence of type 2 diabetes mellitus and coronary artery disease. Diabet Med 18, 842-845.
  • Ortlepp, J. R., Metrikat, J., Albrecht, M., von Korff, A., Hanrath, P., and Hoffmann, R. (2003). The vitamin D receptor gene variant and physical activity predicts fasting glucose levels in healthy young men. Diabet Med 20, 451-454.
  • Ostgren, C. J., Lindblad, U., Melander, O., Melander, A., Groop, L., and Rastam, L. (2003). Peroxisome proliferator-activated receptor-gammaPro12Ala polymorphism and the association with blood pressure in type 2 diabetes: skaraborg hypertension and diabetes project. J Hypertens 21, 1657-1662.
  • Ota, N., Hunt, S. C., Nakajima, T., Suzuki, T., Hosoi, T., Orimo, H., Shirai, Y., and Emi, M. (2000). Linkage of human tumor necrosis factor-alpha to human osteoporosis by sib pair analysis. Genes Immun 1, 260-264.
  • Ota, N., Nakajima, T., Nakazawa, I., 2001, “A nucleotide variant in the promoter region of the IL-6 gene associated with decreased bone mineral density”, J Hum Genet, 46:5, 267-72.
  • Ota, N., Nakajima, T., Nakazawa, I., Suzuki, T., Hosoi, T., Orimo, H., Inoue, S., Shirai, Y., and Emi, M. (2001). A nucleotide variant in the promoter region of the interleukin-6 gene associated with decreased bone mineral density. J Hum Genet 46, 267-272.
  •  Otani, T., Iwasaki, M., Hanaoka, T., 2005, “Folate, vitamin B6, vitamin B12, and vitamin B2 intake, genetic polymorphisms of related enzymes, and risk of colorectal cancer in a hospital-based case-control study in Japan”, Nutr Cancer, 53:1, 42-50.
  • Padovani, V.J., Filho, A.P., Simoes, M.V., 2000, “Gene polymorphisms in the TNF locus and the risk of myocardial infarction”, 100, 263-269.
  • Palli, D., Masala, G., Peluso, M., Gaspari, L., Krogh, V., Munnia, A., Panico, S., Saieva, C., Tumino, R., Vineis, P., and Garte, S. (2004). The effects of diet on DNA bulky adduct levels are strongly modified by GSTM1 genotype: a study on 634 subjects. Carcinogenesis. 2004 Apr;25(4):577-84.
  • Palli, D., Masala, G., Vineis, P., Garte, S., Saieva, C., Krogh, V., Panico, S., Tumino, R., Munnia, A., Riboli, E., and Peluso, M. (2003). Biomarkers of dietary intake of micronutrients modulate DNA adduct levels in healthy adults. Carcinogenesis 24, 739-746.
  • Palli, D., Saieva, C., Gemma, S., 2005, “GSTT1 and GSTM1 gene polymorphisms and gastric cancer in a high-risk Italian population”, Int J Canc, 115, 284-9.
  • Paolisso, G., Tagliamonte, M. R., De Lucia, D., Palmieri, F., Manzella, D., Rinaldi, C., Bossone, A., Colaizzo, D., Margaglione, M., and Varricchio, M. (2001). ACE gene polymorphism and insulin action in older subjects and healthy centenarians. J Am Geriatr Soc 49, 610-614.
  • Paracchini V, Pedotti P, Taioli E. Genetics of leptin and obesity: a HuGE review. American Journal of Epidemiology 2005; 162(2):101–114.
  • Paradis A-M, Fontaine-Bisson B, Bosse Y, Robitaille J, Lemieux S, Jaques H, Lamarche B, Tchernof A, Couture P, Vohl M-C. The peroxisome proliferator-activated receptor Leu162Val polymorphism influences the metabolic response to a dietary intervention altering fatty acid proportions in healthy men. Am J Clin Nutr 81: 523-30, 2005.
  • Partridge L, Barton NH. Evolution of Aging – Testing the Theory Using Drosophila. Genetica 1993. 91(1-3): 89- 98.
  • Pasquale, D.P., Cannizzaro, S., Scalzo, S., 2005, “Cardiovascular effects of I/D angiotensin-converting enzyme gene polymorphism in healthy subjects. Findings after follow-up of six years”, Acta Cardiol, 60:4, 427-35.
  • Paterna, S., Pasquale, D.P., D’Angelo, A., 2000, “Angiotensin-converting enzyme gene deletion polymorphism determines an increase in frequency of migraine attacks in patients suffering from migraine without aura”, Eur Neurol, 43:3, 133-6.
  • Pavanello, S., Clonfero, E., 2000, “Biological indicators of genotoxic risk and metabolic polymorphisms”, Mut Res, 463, 285-308.
  • Pawelec G, Akbar A, Caruso C, Effros R, Grubeck-Loebenstein B, Wikby A. Is immunosenescence infectious? Trends Immunol. 2004;25:406–410.
  • Pawelec G, Ouyang Q, Colonna-Romano G, Candore G, Lio D, Caruso C. Is human immunosenescence clinically relevant? Looking for ‘immunological risk phenotypes’. Trends Immunol. 2002;23:330–332.
  •  Pearl R. The Rate of Living. 1928. University of London Press, London.
  • Pereira M, Swain J, Goldfine A, Rifai N, Ludwig D. Effects of a low-glycemic load diet on resting energy expenditure and heart disease risk factors during weight loss. JAMA 292(20): 2482-2490, 2004.
  • Perera, F. P. and I. B. Weinstein (2000) Molecular epidemiology: recent advances and future directions. Carcinogenesis 21(3): 517-24.
  • Perera, F.P., Money, L.V.A., Stampfer, M., 2002, “Associations between carcinogen–DNA damage, glutathione S-transferase genotypes, and risk of lung cancer in the prospective Physicians’ Health Cohort Study”, Carcinogenesis, 23:10, 1641-6.
  • Peris, P., Alvarez, L., Oriola, J., Guanabens, N., Monegal, A., de Osaba, M. J., Jo, J., Pons, F., Ballesta, A. M., and Munoz-Gomez, J. (2000). Collagen type Ialpha1 gene polymorphism in idiopathic osteoporosis in men. Rheumatology (Oxford) 39, 1222-1225.
  • Perls T, Shea-Drinkwater M, Bowen-Flynn J, et al. Exceptional familial clustering for extreme longevity in humans. J Am Geriatr Soc 2000;48:1483–5.
  • Persistent Microalbuminuria and Severe Nephropathy in Type 1 Diabetes”, Diabetes, 54, 1238-44.
  • Perticone, F., Ceravolo, R., Iacopino, S., Cloro, C., Ventura, G., Maio, R., Gulletta, E., Perrotti, N., and Mattioli, P. L. (2001). Relationship between angiotensin-converting enzyme gene polymorphism and insulin resistance in never-treated hypertensive patients. J Clin Endocrinol Metab 86, 172-178.
  • Perusse L, Rantinen T, Zuberi A, Changon T, Weisnagel SJ, Argyropoulos G, Walts B Synder EE, Bouchard C. The human obesity gene map: the 2004 update. Obesity Res 2005 Mar;13(3):381-490.
  • Phares DA, Halverstadt AA, Shuldiner AR, Ferrell RE, Douglass LW, Ryan AS, Goldberg AP, and Hagberg JM. Association between body fat response to exercise training and multilocus ADR genotypes. Obes Res 12: 807- 815, 2004.
  • Pharoah PD, Antoniou AC, Easton DF, Ponder BA. Polygenes, risk prediction, and targeted prevention of breast cancer. N Engl J Med. 2008;358(26):2796-803.
  • Pietrzyk, J.J., Multanowski, M.B., Sanak, M., 2003, “Polymorphisms of the 5,10-methylenetetrahydrofolate and the methionine synthase reductase genes as independent risk factors for spina bifida”, J Appl Genet, 44:1, 111- 3.
  • Pihusch, R., Danzl, G., Scholz, M., 2002, “Impact of Thrombophilic Gene Mutations on Thrombosis Risk in Patients with Gastrointestinal Carcinoma”, Cancer, 94:31, 20-6.
  • Pinarbasi, H., Silig, Y., Cetinkaya, Oge, 2003, “Strong association between the GSTM1-null genotype and lung cancer in a Turkish population”, Canc Genet Cytogenet, 146, 125-29.
  • Poirier, O., Nicaud, V., Cambien, F., and Tiret, L. (2000). The Pro12Ala polymorphism in the peroxisome proliferator-activated receptor gamma2 gene is not associated with postprandial responses to glucose or fat tolerance tests in young healthy subjects: the European Atherosclerosis Research Study II. J Mol Med 78,346- 351.
  • Policy issues – Personalised Medicine [cited 2012 01.08.2012]. Available from: http://ec.europa.eu/research/health/policy-issues-personalised-medicine_en.html.
  • Pollex R, Hanley A, Zinman B, Harris S, Khan H, Hegele R. Metabolic syndrome in aboriginal Canadians: prevalence and genetic associations. Atherosclerosis 184: 121-129, 2006.
  • Popkin, B. M. (2002). An overview on the nutrition transition and its health implications: The Bellagio Meeting. Public Health Nutrition 5(1A):93-103.
  • Popovic, K., Ek, M., Espinoza, E., 2005, “Increased expression of the novel proinflammatory cytokine high mobility group box chromosomal protein 1 in skin lesions of patients with lupus erythematosus”, Arthritis &Rheumatism, 52:11, 3639-45.
  • Poulsen, P., Andersen, G., Fenger, M., Hansen, T., Echwald, S. M., Volund, A., Beck-Nielsen, H., Pedersen, O., and Vaag, A. (2003). Impact of two common polymorphisms in the PPARgamma gene on glucose tolerance and plasma insulin profiles in monozygotic and dizygotic twins: thrifty genotype, thrifty phenotype, or both?Diabetes 52, 194-198.
  • Poulsen, P., Andersen, G., Fenger, M., Hansen, T., Echwald, S. M., Volund, A., Beck-Nielsen, H., Pedersen, O., and Vaag, A. (2003). Impact of two common polymorphisms in the PPARgamma gene on glucose tolerance and plasma insulin profiles in monozygotic and dizygotic twins: thrifty genotype, thrifty phenotype, or both? Diabetes 52, 194-198.
  • Povel CM, Boer JM, Reiling E, Feskens EJ. Genetic variants and the metabolic syndrome: a systematic review. Obes Rev. 2011 Nov;12(11):952-67.
  • Prentice, A. (2001). The relative contribution of diet and genotype to bone development. Proc Nutr Soc 60,45- 52.
  • Promoter on High-Density Lipoprotein Metabolism, Evidence of a Strong Dose Effect in This Gene-Nutrient Interaction in the Framingham Study. Circulation, 106: 2315-2321.
  • Purdie, D., Spurdle, A., et al. (2002) Dietary antioxidants, manganese superoxide dismutase (MnSOD), and risk of epithelial ovarian cancer. Proc. American Assoc. for Cancer Res. 43: 4227.
  • Ralston, S. H. (2002). Genetic control of susceptibility to osteoporosis. J Clin Endocrinol Metab 87, 2460-2466.
  • Ramachandran, S., A. A. Fryer, et al. (2001) Basal cell carcinomas: association of allelic variants with a high-risk subgroup of patients with the multiple presentation phenotype. Pharmacogenetics 11(3): 247-54.
  • Ramsay, H. M., P. N. Harden, et al. (2001) Polymorphisms in glutathione S-transferases are associated with altered risk of nonmelanoma skin cancer in renal transplant recipients: a preliminary analysis. J Invest Dermatol 117(2): 251-5.
  • Ranganathan, A. C., K. K. Nelson, et al. (2001) Manganese superoxide dismutase signals matrix metalloproteinase expression via H2O2-dependent ERK1/2 activation. J Biol Chem 276(17): 14264-70.
  • Rankinen T, Zuberi A, Chagnon YC, Weisnagel J, Argyropoulos G, et al. The human obesity gene map: The 2005 update. Obesity 14: 529-644, 2005.
  • Rankinen T, Zuberi A, Chagnon YC, Weisnagel SJ, Argyropoulos G, Walts B, Pérusse L, Bouchard C. The human obesity gene map: the 2005 update. Obesity (2006) 14: 529-644.
  • Rapuri, P. B., Gallagher, J. C., Kinyamu, H. K., and Ryschon, K. L. (2001). Caffeine intake increases the rate of bone loss in elderly women and interacts with vitamin D receptor genotypes. Am J Clin Nutr 74, 694-700.
  • Reding KW, Chen C, Lowe K, et al. Estrogen-related genes and their contribution to racial differences in breast cancer risk. Cancer Causes Control. 2012 May;23(5):671-81.
  • Regierer B, Zazzu V, Sudbrak R, Kühn A, Lehrach H. Future of Medicine: Models in Predictive Diagnostics and Personalized Medicine. In: Seitz H, Schumacher S, editors. Molecular Diagnostics. Advances in Biochemical Engineering/Biotechnology. 133: Springer Berlin Heidelberg; 2013. p. 15-33.
  • Relton, C.L., Wilding, C.S., Pearce, M.S., 2004, “Gene-gene interaction in folate related genes and risk of neural tube defects in a UK population”, J Med Genet, 41, 256-260.
  • Relvas, W.G.M., Izar, M.C.O., Helfenstein, T., Fonseca, Colovati, M.I.H., Oliveira M. A., Atherosclerosis 178, 101–105.
  • Ren, M. Q., Kuhn, G., Wegner, J., and Chen, J. (2001). Isoflavones, substances with multi-biological and clinical properties. Eur J Nutr 40, 135-146.
  • Revilla, M., Obach, V., Cervera, A., Davalos, A., Castillo, J., and Chamorro, A. (2002). A -174G/C polymorphism of the interleukin-6 gene in patients with lacunar infarction. Neurosci Lett 324, 29-32.
  • Ridker, P.M., Cook, N.R., Cheng, S., 2003, “Alanine for Proline Substitution in the Peroxisome Proliferator– Activated Receptor Gamma-2 (PPAR 2) Gene and the Risk of Incident Myocardial Infarction”, Arterioscler Thrombos Vasc Biol, 23, 859-63.
  • Ridley, M. Genome: The Autobiography of a Species in 23 Chapters. Fourth Estate Ltd; New edition edition (16 Mar 2000).
  • Rigo, J., Nagy, B., Fintor, L., 2000, “Maternal and neonatal outcome of preeclamptic pregnancies: the potential role of factor V leiden mutation and 5,10 MTHFR”, Hypertension in Pregnancy, 19:2, 163-72.
  • Ritchie MD, Denny JC, Crawford DC, Ramirez AH, Weiner JB, Pulley JM, et al. Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record. Am J Hum Genet. 2010;86(4):560-72.
  • Rizzoli, R., Bonjour, J. P., and Ferrari, S. L. (2001). Osteoporosis, genetics and hormones. J Mol Endocrinol 26,79-94.
  • Roberts NJ, Vogelstein JT, Parmigiani G, Kinzler KW, Vogelstein B, Velculescu VE. The Predictive Capacity of Personal Genome Sequencing. Sci Transl Med. 2012.
  • Robitaille J, Despres JP, Perusse L, and Vohl MC. The PPAR-gamma P12A polymorphism modulates the relationship between dietary fat intake and components of the metabolic syndrome: results from the Quebec Family Study. Clin Genet 63: 109-116, 2003.
  • Rock CL, Doyle C, Demark-Wahnefried W, Meyerhardt J, Courneya KS, Schwartz AL, Bandera EV, Hamilton KK, Grant B, McCullough M, Byers T, Gansler T. Nutrition and physical activity guidelines for cancer survivors. CA Cancer J Clin 2012 Jul;62(4):242-74.
  • Rock, C.L, Lampe, J.W. (2000) Nutrition, genetics, and risks of cancer.Annu Rev Public Health. 21:47-64.
  • Rodriguez, G.R.M., Juilliere, R., Candito, M., 2005, “Association of MTRRA66G polymorphism (but not of MTHFR C677T and A1298C, MTRA2756G, TCN C776G) with homocysteine and coronary artery disease in the French population”, Thromb Haemost, 94:3, 510-5.
  • Rodriguez, R.M.G., Rendeli, C., Namour, B., 2003, “Transcobalamin and methionine synthase reductase mutated polymorphisms aggravate the risk of neural tube defects in humans”, Neurosci Lett, 344, 189-92
  • Roggia, C., Gao, Y., Cenci, S., Weitzmann, M. N., Toraldo, G., Isaia, G., and Pacifici, R. (2001). Up-regulation of TNF-producing T cells in the bone marrow: a key mechanism by which estrogen deficiency induces bone loss in vivo. Proc Natl Acad Sci U S A 98, 13960-13965.
  • Rojas, M, Cascorbi, I., et al. (2000) Modulation of benzo[a]pyrene dioepoxide-DNA addcut levels in human white blood cells by CYP1A1, GSTM1, and GSTT1 polymorphism. Carcinogenesis 21:35-41.
  • Romero-Corral A, Montori VM, Somers VK, Korinek J, Thomas RJ, Allison TG, Mookadam F, Lopez-Jimenez F. Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: a systematic review of cohort studies. Lancet. 2006 Aug 19;368(9536):666-78.
  • Romieu, I., Sienra-Monge, J. J., Ramirez-Aguilar, M., Moreno-Macias, H., Reyes-Ruiz, N. I., Estela del Rio- Navarro, B., Hernandez-Avila, M., and London, S. J. (2004). Genetic polymorphism of GSTM1 and antioxidant supplementation influence lung function in relation to ozone exposure in asthmatic children in Mexico City.Thorax 59, 8-10.
  • Rook, J.L., Nugent, D.J., Young, G., 2005, “Pediatric stroke and methylenetetrahydrofolate reductase polymorphisms”, J Pediatr Hematol Oncol, 27, 590-593.
  • Rosendaal, F.R., 2005, “Venous Thrombosis: The Role of Genes, Environment, and Behavior”, Hematology Am Soc Hematol Educ Program, 1-12.
  • Rosenzweig JL, Ferrannini E, Grundy SM, Haffner SM, Heine RJ, Horton ES, Kawamori R, Endocrine Society. Primary prevention of cardiovascular disease and type 2 diabetes in patients at metabolic risk: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2008 Oct;93(10):3671-89.
  • Rosmond, R., Chagnon, M., Bouchard, C., and Bjorntorp, P. (2001). G-308A polymorphism of the tumor necrosis factor alpha gene promoter and salivary cortisol secretion. J Clin Endocrinol Metab 86, 2178-2180.
  • Rost S, Fregin A, Ivaskevicius V, et al. Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2. Nature. 2004;427:537-541.
  • Rozen, R. (2000). Genetic modulation of homocysteinemia. Semin Thromb Hemost 26, 255-261.
  • Ruiz, A.G.J., Garces, A.J., Reyes, N.V., 2001, “Primary thrombophilia in Mexico. II. Factor V G1691A (Leiden), prothrombin G20210A, and methylenetetrahydrofolate reductase C677T polymorphism in thrombophilic Mexican mestizos”, Am J Hematol, 66:1, 28-31.
  • Ruiz, N.E.A., Yang, Y., Nakanishi, Y., 2005, “APOC3/A5 haplotypes , lipid levels and risk of myocardial infarction in the central valley of Costa Rika”, J Lipid Res, 46:12, 2605-13.
  • Ryan, A. S., Nicklas, B. J., Berman, D. M., and Ferrell, R. E. (2001). The insertion/deletion polymorphism of the ACE gene is related to insulin sensitivity in overweight women. Diabetes Care 24, 1646-1652.
  • Sachdeva, R. M., Heyworth, M. F., et al. (2001) The SOD2 Val 16 Ala polymorphism and prostate cancer.American Journal of human genetics 69(4 Supplement):261.
  • Sagoo GS, Tatt I, Salanti G, et al. Seven lipoprotein lipase gene polymorphisms, lipid fractions, and coronary disease: a HuGE association review and meta-analysis. Am J Epidemiol. 2008 Dec 1;168(11):1233-46.
  • Salvarani, C., Casali, B., Nicoli, D., 2003, “Endothelial Nitric Oxide Synthase Gene Polymorphisms in Giant Cell Arteritis”, Arthritis Rheum, 48:11, 3219-23.
  • Sanderson S, Emery J, Higgins J. CYP2C9 gene variants, drug dose, and bleeding risk in warfarin-treated patients: a HuGEnet systematic review and meta-analysis. Genet Med. 2005 Feb;7(2):97-104.
  • Sarbia, M., Stahl, M., Weyhern, V.C., 2006, “The prognostic significance of genetic polymorphism in multidomally treated oesophageal squamous cell acrcinoma”, Br J Cancer, 94:2, 203-7.
  • Sarmanova, J., Susova, S., Gut, I., 2004, “Breast cancer: role of polymorphisms in biotransformation enzymes”, 12:10, 848-54.
  • Sass, C., Herbeth, B., Siest, G., 2000, “Lipoprotein lipase (C/G)447 polymorphism and blood pressure in the Stanislas Cohort”, J Hypertens, 18, 1775-81.
  • Satman I, Yilmaz T, Sengul A, Salman S, Salman F, Uygur S, Bastar I, Tutuncu Y, Sargin M, Dinccag N, Karsidag K, Kalaca S, Ozcan C, King H. Population-based study of diabetes and risk characteristics in Turkey: results of the Turkish diabetes epidemiology study (TURDEP). Diabetes Care. 2002 Sep;25(9):1551-6.
  • Sato, M., T. Sato, et al. (2000) Genetically high susceptibility to oral squamous cell carcinoma in terms of combined genotyping of CYP1A1 and GSTM1 genes. Oral Oncol 36(3): 267-71.
  • Savano, M., Watanabe, Y., Ohmura, H., 2001, “Potentially Protective Effects of the Ser447-Ter Mutation of the Lipoprotein Lipase Gene Against the Development of Coronary Artery Disease in Japanese Subjects Via a Beneficial Lipid Profile”, Jpn Circ J, 65, 310-14.
  • Savas B. A Case in Commercial Applications of Nutrigenetics. Abstract A31. In: 1st Congress of the International Society of Nutrigenetics/Nutrigenomics (ISNN). 2007;1(1-2):72. Epub 16.10.2007.
  • Savas BS, Cesuroglu T. Health for America: European Arguments for a Paradigm Shift. In: Shah A, Colombano J, editors. Learning from the World: New Ideas to Redevelop America Palgrave Macmillan; 2013. p. 169-86.
  • Savas BS, et al. In Thomson S and Mossialos E eds. Health care systems in transition: Turkey. Copenhagen, European Observatory on Health Care Systems 2002; 4(4).
  • Schauer P, Ikramuddin S, Hamad G, Gourash W. The learning curve for laparoscopic Roux-en-Y gastric bypass is 100 cases. Surg Endosc. 2003 Feb;17(2):212-5.
  • Schiele F, DeBacquer D, Vincent-Viry M, et al.(2000) Apolipoprotein E serum concentration and polymorphism in six European countries: the ApoEurope Project. Atherosclerosis 152:475–88.
  • Schnakenberg, E., Breuer, R., Werdin, R., 2000, “Susceptibility genes: GSTM1 and GSTM3 as genetic risk factors in bladder cancer”, Cytogenet Cell Genet, 91:1-4, 234-8.
  • Schoket, B.; Papp, G, et al. (2001) Impact of metabolic genotypes on levels of biomarkers of genotoxic exposure. Mutation Research 482: 57-69.
  • Sconce EA, Khan TI, Wynne HA, Avery P, Monkhouse L, King BP, Wood P, Kesteven P, Daly AK, Kamali F. The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements: proposal for a new dosing regimen.Blood. 2005 Oct 1;106(7):2329-33.
  • Seckin, D., Ilhan, N., Ilhan, N., 2006, “The relationship between ACE insertion/deletion polymorphism and coronary artery disease with or without myocardial infarction”, Clin Biochem, 39, 50-54.
  • Selvaraj, P., Sriram, U., Mathan, K.S., 2001, “TNF- (-238 and -308) and beta gene polymorphism in pulmonary tuberculosis”, Tuberculosis, 81:5-6, 335-41.
  • Seow, A., Yuan, J. M., Sun, C. L., Van Den Berg, D., Lee, H. P., and Yu, M. C. (2002). Dietary isothiocyanates, glutathione S-transferase polymorphisms and colorectal cancer risk in the Singapore Chinese Health Study. Carcinogenesis 23, 2055-2061.
  • Serrano, N.C., Casas, J.P., Diaz, L.A., 2004, “Endothelial NO Synthase Genotype and Risk of Preeclampsia: A Multicenter Case-Control Study”, Hypertension, 44, 702-7.
  • Sharp L, Little J.,2004, “Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review”, Am J Epidemiol, 159:5,423-43.
  • Sheehan, D., Bennett, T., and Cashman, K. D. (2001). An assessment of genetic markers as predictors of bone turnover in healthy adults. J Endocrinol Invest 24, 236-245.
  • Shekelle PG, Morton SC, Maglione MA, Suttorp M, Tu W, Li Z, et al. Pharmacological and Surgical Treatment of Obesity. Evidence Report/Technology Assessment No. 103. Prepared by the Southern California–RAND Evidence-Based Practice Center, Santa Monica, California, under contract no. 290-02-0003. AHRQ publication no. 04-E028-2. Rockville, MD: Agency for Healthcare Research and Quality; July 2004.
  • Shemelava, M.V., Kapustin, S.I., Papayan, L.P., 2003, “Prevalence of hyperhomocysteinemia and the MTHFR C677T polymorphism in patients with arterial and venous thrombosis from North Western Russia”, Thrombosis Res, 111, 351-356.
  • Shiau, M. Y., Wu, C. Y., Huang, C. N., Hu, S. W., Lin, S. J., and Chang, Y. H. (2003). TNF-alpha polymorphisms and type 2 diabetes mellitus in Taiwanese patients. Tissue Antigens 61, 393-397.
  • Shiau, M.Y., Wu, C.Y., Huang, C.N., 2003, “TNF- polymorphisms and type 2 diabetes mellitus in Taiwanese patients”, Tissue Antigens, 61, 393-7.
  • Shields, P. G. and C. C. Harris (2000) Cancer risk and low-penetrance susceptibility genes in geneenvironment interactions. J Clin Oncol 18(11): 2309-15.
  • Shiwaku K, Nogi A, Anuurad E, Kitajima K, Enkhmaa B, Shimono K, and Yamane Y. Difficulty in losing weight by behavioral intervention for women with Trp64Arg polymorphism of the beta3-adrenergic receptor gene. Int J Obes Relat Metab Disord 27: 1028-1036, 2003.
  • Shiwaku K, Nogi A, Anuurad E, Kitajima K, Enkhmaa B, Shimono K, Yamane Y. Difficulty in losing weight by behavioral intervention for women with Trp64Arg polymorphism of the beta3-adrenergic receptor gene. Int J Obes Relat Metab Disord. 2003 Sep;27(9):1028-36.
  • Shmeleva VM, Kapustin S.I, Papayan LP, Sobczynska-Malefora A, Harrington DJ, Savidge GF. Prevalence of hyperhomocysteinemia and the MTHFR C677T polymorphism in patients with arterial and venous thrombosis from North Western Russia. Thromb Res. 2003;111, 351-356.
  • Silaste, M. L., Rantala, M., Sampi, M., Alfthan, G., Aro, A., and Kesaniemi, Y. A. (2001). Polymorphisms of key enzymes in homocysteine metabolism affect diet responsiveness of plasma homocysteine in healthy women.J Nutr 131, 2643-2647.
  • Silva PS, Lacchini R, Gomes Vde A, Tanus-Santos JE. Pharmacogenetic implications of the eNOS polymorphisms for cardiovascular action drugs. Arq Bras Cardiol. 2011 Feb;96(2):e27-34.
  • Simmons LA, Dinan MA, Robinson TJ, Snyderman R. Personalized medicine is more than genomic medicine: confusion over terminology impedes progress towards personalized healthcare. Personalized Medicine. 2011;9(1):85-91.
  • Simopoulos, A. P. (2004) Genetic variation: nutritional implications. Simpoulos, A. P., Ordovas, J. M. (eds): Nutrigenetics and Nutrigenomics. World Rev Nutr Diet. Basel, Karger, vol 93, pp 1-28.
  • Simpoulos AP, Ordovas JM (eds). Nutrigenetics and Nutrigenomics. World Rev Nutr Diet 2004; vol 93, pp 1-28.
  • Sing CF, Moll PP. (1989) Genetics of variability of CHD risk. Int J Epidemiol 18 (suppl 1): S183–S195 .
  • Sing, C. H., Stengard, J. H., Kardia, S. L. R. (2004). Dynamic relationships between the genome and exposures to environments as causes of common human diseases. Simpoulos, A. P., Ordovas, J. M. (eds): Nutrigenetics and Nutrigenomics. World Rev Nutr Diet. Basel, Karger, vol 93, pp 77-91.
  • Singapore Ministry of Health (MOH). Obesity. Singapore Ministry of Health – National Government Agency 2004.
  • Siobhán Cusack; Kevin D. Cashman,2003, “ Impact of genetic variation on metabolic response of bone to diet”, Proceedings of the Nutrition Society, 62: 4, 901-912.
  • Skibola, C.B., Forrest, M.S., Coppede, F., 2004, “Polymorphism and haplotypes in folate metabolizing genes and risk of non-Hodgkin lymphoma”, Blood, 104:7, 2155-62.
  • Slatter, M. L., Yakumo, K., Hoffman, M., and Neuhausen, S. (2001). Variants of the VDR gene and risk of colon cancer (United States). Cancer Causes Control 12, 359-364.
  • Sleegers, K., Heijer, T.D., Dijk, E.D.J., 2005, “ACE gene is associated with Alzheimer’s disease and atrophy of hippocampus and amygdala”, Neurobiol Aging, 1153-9.
  • Slooter, A.J., Rosendaal, F.R., Tanis, B.C., Kemmeren, J.M., van der Graaf, Y., Algra, A.J., 2005, “Prothrombotic conditions, oral contraceptives, and the risk of ischemic stroke.”, Thromb Haemost. 3(6):1213-7.
  • Snow V, Barry P, Fitterman N, Qaseem A, Weiss K. Pharmacologic and Surgical Management of Obesity in Primary Care: A Clinical Practice Guideline from the American College of Physicians. Ann Intern Med. 2005;142:525-531.
  • Sookinan, S.C., Gonzalez, C., Pirola, C.J., 2005, “Meta analysis on the G-308A TNF- gene variant and phenotypes associated with the metabolic syndrome”, Obes Res, 13:12, 2122-31
  • Sorensen K, Brand H. Health literacy: the essential catalyst for the responsible and effective translation of genome-based information for the benefit of population health. Public Health Genomics. 2011;14(4-5):195-200.
  • Sørensen TIA, Boutin P, Taylor MA, Larsen LH, Verdich C, et al. Genetic polymorphisms and weight loss in obesity: A randomised trial of hypo-energetic high- versus low-fat diets. PLoS Clin Trials 2006; 1(2): e12.
  • Sorensen, M., Autrup, H., Tjonneland, A., 2004, “Glutathione S-Transferase T1 Null-Genotype is Associated with an Increased Risk of Lung Cancer”, Int J Canc, 110, 219-24.
  • Soucek, P. (2001) Role of genetic factors in development and progression of non-Hodgkin’s lymphomas.Cent Eur J Public Health 9(2): 74-8.
  • Speer, G., Cseh, K., Winkler, G., 2001, “Vitamin D and estrogen receptor gene polymorphisms in type 2 diabetes mellitus and in android type obesity.”, Eur J Endocrinol., 144(4):385-9.
  • Speer, G., Cseh, K., Winkler, G., Vargha, P., Braun, E., Takacs, I., and Lakatos, P. (2001). Vitamin D and estrogen receptor gene polymorphisms in type 2 diabetes mellitus and in android type obesity. Eur J Endocrinol 144,385-389.
  • Spiteri, M. A., A. Bianco, et al. (2000) Polymorphisms at the glutathione S-transferase, GSTP1 locus: a novel mechanism for susceptibility and development of atopic airway inflammation. Allergy 55(Suppl 61): 15-20.
  • Sreeja, L., Syamala, V., Hariharan, S., 2005, “Possible risk modification by CYP1A1, GSTM1 and GSTT1 gene polymorphisms in lung cancer susceptibility in a South Indian population”, J Hum Genet, 50, 618-27.
  • Standards of medical care in diabetes. IV. Prevention/delay of type 2 diabetes. Diabetes Care 2012 Jan;35(Suppl 1):S16.
  • Stankiewicz P, Lupski JR. Structural variation in the human genome and its role in disease. Annu Rev Med. 2010;61:437-55.
  • Stanulla, M., M. Schrappe, et al. (2000) Polymorphisms within glutathione S-transferase genes (GSTM1,GSTT1, GSTP1) and risk of relapse in childhood B-cell precursor acute lymphoblastic leukemia: a case-control study. Blood 95(4): 1222-8.
  • Starfield B, Holtzman NA, Roland MO, Sibbald B, Harris R, Harris H. Primary care and genetic services. Health care in evolution. Eur J Public Health. 2002 Mar;12(1):51-6.
  • Steering Group on Strategic Implementation Plan for the European Innovation Partnership on Active and Healthy Ageing. Stratgic Plan. 2011 17 Nov 2011.
  • Steinhoff, C., K. H. Franke, et al. (2000) Glutathione transferase isozyme genotypes in patients with prostate and bladder carcinoma. Arch Toxicol 74(9): 521-6.
  • Steinkellner, H., Rabot, S., et al. (2001) Effects of cruciferous vegetables and their constituents on drug metabolizing enzymes involved in the bioactivation of DNA-reactive dietary carcinogens. Mutation Research 480-481: 285-297.
  • Stenvinkel, P., Filho, R.B., Lindholm, B., 2005, “Gene polymorphism association studies in dialysis: the nutrition –inflammation axis”, Seminars in Dialysis, 18:4, 322-30.
  • Stern, L. L., Bagley, P. J., Rosenberg, I. H., and Selhub, J. (2000). Conversion of 5-formyltetrahydrofolic acid to 5-methyltetrahydrofolic acid is unimpaired in folate-adequate persons homozygous for the C677T mutation in the methylenetetrahydrofolate reductase gene. J Nutr 130, 2238-2242.
  • Stoehlmacher, J. Ingles, S. et al. (2000) A genetic polymorphism of manganese superoxide dismutase (MnSOD) predicts for risk of colorectal cancer in young individuals. Annal of Oncology 11(Suppl 4): 59.
  • Stoehlmacher, J., Ingles, S.A., Park, D.J., 2002, “The -9Ala/-9Val polymorphism in the mitochondrial targetting sequence of the MnSOD is associated with age among Hispanics with colorectal carcinoma”, Oncol Rep, 2, 235-8.
  • Stolzenberg, R.Z.S., Qiao, Y.L., Abnet, C.C., 2003, “Esophageal and Gastric Cardia Cancer Risk and Folate-and Vitamin B12-related Polymorphisms in Linxian, China”, Canc Epidemiol Biomarkers Prev, 12, 1222-6.
  • Strain, J.J., Dowey, L., Ward, M., 2004, “B vitamins, homocysteine metabolism and CVD”, Proceedings in Nutrition Society, 63, 597-603.
  • Strange, R. C., M. A. Spiteri, et al. (2001) Glutathione-S-transferase family of enzymes. Mutat Res 482(1-2):21- 6.
  • Stratified Medicine in the UK: Vision and Roadmap. Technology Strategy Board. October 2011. Swindon, UK.
  • Stuber, F. (2001). Effects of genomic polymorphisms on the course of sepsis: is there a concept for gene therapy? J Am Soc Nephrol 12 Suppl 17, S60-64.
  • Stucker, I., M. Jacquet, et al. (2000) Relation between inducibility of CYP1A1, GSTM1 and lung cancer in a French population. Pharmacogenetics 10(7): 617-27.
  • Stumvoll, M., and Haring, H. (2001). Insulin resistance and insulin sensitizers. Horm Res 55 Suppl 2, 3- 13.Stumvoll, M., and Haring, H. (2002). The peroxisome proliferator-activated receptor-gamma2 Pro12Ala polymorphism. Diabetes 51, 2341-2347.
  • Stumvoll, M., Haring, H., 2002, “The Peroxisome Proliferator–Activated Receptor-gamma2 Pro12Ala Polymorphism”, Diabetes, 51, 2341-7.
  • Su MT, Lin SH, Chen YC. Genetic association studies of angiogenesis- and vasoconstriction-related genes in women with recurrent pregnancy loss: a systematic review and meta-analysis. Hum Reprod Update. 2011 Nov- Dec;17(6):803-12.
  • Suarez, A., Lopez, P., Mozo, L., 2005, “Differential effect of IL10 and TNF alpha genotypes on determining susceptibility to discoid and systemic lupus erythematosus”, Ann Rheum Dis, 64:11, 1605-10.
  • Svetkey, L. P., Moore, T. J., Simons-Mortorf, D. G., Apel, L. J., Bray, G. A., Sacks, F. M., Ard, J. D., Mortensen, R. M., Mistchell, S. R., Contin, P. R., Kesari, M. for the DASH Colloborative Research Group (2001). Angiotensinogen genotype and blood pressure response in the Dietary Approaches to Stop Hypertension (DASH) study. J Hypertension 2001;19:1949-1956.
  • Sweeney, C., D. C. Farrow, et al. (2000) Glutathione S-transferase M1, T1, and P1 polymorphisms as risk factors for renal cell carcinoma: a case-control study. Cancer Epidemiol Biomarkers Prev 9(4): 449-54.
  • Sweeney, C., G. Y. McClure, et al. (2000) Association between survival after treatment for breast cancer and glutathione S-transferase P1 Ile105Val polymorphism. Cancer Res 60(20): 5621-4.
  • Swenberg, J. A.; Koc, H, et al. (2001) Using DNA and hemoglobin adducts to improve the risk assessment of butadiene. Chem. Biol. Interact. 135-136: 387-403.
  • Sykes, T.C.F., Fegan, C., Mosquera, D., 2000, “Thrombophilia, polymorphisms, and vascular disease”, J Clin Pathol: Mol Pathol, 53, 300-6.
  • Szczeklik, A., Sanak, M., Jankowski, M., Dropinski, J., Czachor, R., Musial, J., Axenti, I., Twardowska, M., Brzostek,T., and Tendera, M. (2001). Mutation A1298C of methylenetetrahydrofolate reductase: risk for early coronary disease not associated with hyperhomocysteinemia. Am J Med Genet 101, 36-39.
  • Talmud, P. J., Humpries, S. E. (2004). Gene:Environment Interactions and Coronary Heart Disease Risk. Simpoulos, A. P., Ordovas, J. M. (eds): Nutrigenetics and Nutrigenomics. World Rev Nutr Diet. Basel, Karger, vol 93, pp 29-40.
  • Tamura, T., Olin, K.L., Goldenberg, R.L., Johnston, K.E., Dubard, M.B. & Keen, C.L. (2001) Plasma extracellular superoxide dismutase activity in healthy pregnant women is not influenced by zinc supplementation. Biol Trace Elem Res, 80, 107-113.
  • Tanis BC, Blom HJ, Bloemenkamp DG, Van Den Bosch MA, Algra A, Van Der Graaf Y, Rosendaal FR. Folate, homocysteine levels, methylenetetrahydrofolate reductase (MTHFR) 677C –> T variant, and the risk of myocardial infarction in young women: effect of female hormones on homocysteine levels. J Thromb Haemost. 2004;2, 35-41.
  • Tate DF, Jackvony EH, Wing RR. Effects of Internet behavioral counseling on weight loss in adults at risk for type 2 diabetes: a randomized trial. JAMA 2003;289:1833–6.
  • Taymaz, H., Erarslan, S., Öner, E.T., 2007, “Sequence variations within the genes related to hemostatic imbalance and their impact on coronary artery disease in Turkish population”, Thrombosis Research, 119(1):55- 62.
  • Terry, C. F., Loukaci, V., and Green, F. R. (2000). Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation. J Biol Chem 275, 18138-18144.
  • Teyssier, C., Amiot, M.J., Mondy, N., Auger, J., Kahane, R. & Siess, M.H. (2001) Effect of onion consumption by rats on hepatic drug-metabolizing enzymes. Food Chem Toxicol, 39, 981-987.
  • Thakkinstian, A., D’Este, C., Eisman, J., 2004, “Meta-analysis of molecular association studies: vitamin D receptor gene polymorphisms and BMD as a case study”, J Bone Miner Res, 19:3, 419-28 the 2002 update”, J Endocr, 177, 147-196.
  • The biology of senescence. 3rd edition. New York: Elsevier North Holland; 1978. p. 1– 414. • The Genomic Revolution: Unveiling the Unity of Life. Eds. Yudell M, DeSalle R. Joseph Henry Press, 2002.
  • The North American Menopause Society. The 2012 hormone therapy position statement of the North American Menopause Society. Menopause 2012 Mar;19(3):257-71
  • Theres, H., Wagner, K.D., Schulz, S., Strube, S., Leiterer, K.P., Romberg, D., Gunther, J., Scholz, H., Baumann, G. & Schimke, I. (2000) Oxygen radical system in chronic infarcted rat heart: the effect of combined beta blockade and ACE inhibition. J Cardiovasc Pharmacol, 35, 708-715.
  • Thier, R., Dommermuth, A. (2001) Haemaglobin adduct levels in acrylonitrile workers depend on hGSTP1 polymorphism. Toxicology Letters 116:99.
  • Thomas, G. N., Critchley, J. A., Tomlinson, B., Lee, Z. S., Young, R. P., Cockran, C. S., and Chan, J. C. (2001).Albuminuria and the renin-angiotensin system gene polymorphisms in type-2-diabetic and in normoglycemic hypertensive Chinese. Clin Nephrol 55, 7-15.
  • Thomas, G.N., Sanderson, J.E., Tomlinson, B., 2001, “Renin-Angiotensin System Gene Polymorphisms, Blood Pressure, Dyslipidemia, and Diabetes in Hong Kong Chinese”, 24, 356-61.
  • Thomas, P. S. (2001). Tumour necrosis factor-alpha: the role of this multifunctional cytokine in asthma. Immunol Cell Biol 79, 132-140.
  • Thuren T. (2000). Hepatic lipase and HDL metabolism. Curr. Opin. Lipidol. 11(3):277-83.
  • Topol EJ. Comment on “The Predictive Capacity of Personal Genome Sequencing”. Sci Transl Med. 2012;4(135):135le5.
  • Topol EJ. Transforming Medicine via Digital Innovation. Sci Transl Med. 2010;2(16):16cm4.
  • Topol, E.J. (2006) The genetics of heart attack. Heart;92(6):855-61. • Torres, M.M., Acosta, C.P., Sicard, D.M., 2004, “Genetic susceptibility and risk of gastric cancer in a human population of Cauca, Colombia”, Biomedica, 24:2, 153-62.
  • Torres, S.L., Chen, J., Diaz, S.Y., 2006, “Dietary and genetic determinants of homocysteine levels among Mexican women of reproductive age”, Eur J Clin Nutr, 1038.
  • Toth PP.Effective management of the type 2 diabetes patient with cardiovascular and renal disease: secondary prevention strategies after a myocardial infarction. Curr Diabetes Rev. 2012 May;8(3):219-28. • Translating Advances in Human Genetics into Public Health Action: A Strategic Plan. Centers For Disease Control And Prevention. Draft September 3, 1997.
  • Tremblay, R., Bonnardeaux, A., Geadah, D., Busque, L., Lebrun, M., Ouimet, D., and Leblanc, M. (2000).Hyperhomocysteinemia in hemodialysis patients: effects of 12-month supplementation with hydrosoluble vitamins. Kidney Int 58, 851-858.
  • Tsai, M. Y., Bignell, M., Yang, F., Welge, B. G., Graham, K. J., and Hanson, N. Q. (2000). Polygenic influence on plasma homocysteine: association of two prevalent mutations, the 844ins68 of cystathionine beta-synthase and A(2756)G of methionine synthase, with lowered plasma homocysteine levels. Atherosclerosis 149,131-137.
  • Tu, A-Y., Albers, JJ. (2001). Glucose regulates the transcription of human genes relevant to HDL metabolism:responsive elements for peroxisome proliferators-activated receptor are involved in the regulation of phospholipids transfer protein. Diabetes, 50: 1851-1856.
  • U.S. Preventive Services Task Force (USPSTF). 1) Screening for breast cancer: U.S. Preventive Services Task Force recommendation statement. 2) December 2009 addendum. Ann Intern Med 2009 Nov 17;151(10):716- 726, W-236.
  • U.S. Preventive Services Task Force (USPSTF). Using nontraditional risk factors in coronary heart disease risk assessment: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med 2009 Oct 6;151(7):474-82.
  • U.S. Preventive Services Task Force. Screening for colorectal cancer: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med 2008 Nov 4;149(9):627-37.
  • U.S. Preventive Services Task Force. Screening for prostate cancer: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med 2012 Jul 17;157(2):120-34.
  • U.S. Preventive Services Task Force. Screening for type 2 diabetes mellitus in adults: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med 2008 Jun 3;148(11):846-54.
  • Ueland PM, Hustad S, Schneede J, Refsum H, Vollset SE. Biological and clinical implications of the MTHFR C677T polymorphism. Trends Pharmacol Sci 2002; 22, 195-201.
  • Uitterlinden, A. G., Weel, A. E., Burger, H., Fang, Y., van Duijn, C. M., Hofman, A., van Leeuwen, J. P., and Pols, H. A. (2001). Interaction between the vitamin D receptor gene and collagen type Ialpha1 gene in susceptibility for fracture. J Bone Miner Res 16, 379-385.
  • Uitterlinden, A.G., van Meurs, J.B., Rivadeneira, F., Pols, H.A. (2006) Identifying genetic risk factors for osteoporosis. J Musculoskelet Neuronal Interact ;6(1):16-26.
  • Uitterlinden, A.G., Weel, A.E., Burger, H., 2001, “Interaction between the vitamin D receptor gene and collagen type Ialpha1 gene in susceptibility for fracture”, J Bone Miner Res, 16:2, 379-85.
  • Ukkola O, Rankinen T, Rice T, Gagnon J, Leon AS, Skinner JS, Wilmore JH, Rao DC, and Bouchard C. Interactions among the ß2- and ß3- adrenergic receptor genes and total body fat and abdominal fat levele in the HERITAGE Family Study. Int J Obes 27: 389-393, 2003.
  • Ukkola O, Tremblay A, and Bouchard C. Beta-2 adrenergic receptor variants are associated with subcutaneous fat accumulation in response to long-term overfeeding. Int J Obes Relat Metab Disord 25: 1604-1608, 2001.
  • Ulusal Hastalık Yükü ve Maliyet-Etkililik Projesi – Hastalık Yükü Final Rapor. TC Sa lık Bakanlı ı Refik Saydam Hıfzıssıhha Merkezi Ba kanlı ı, Hıfzıssıhha Mektebi Müdürlü ü ve Ba kent Üniversitesi. Aralık 2004.
  • Ulvik, A., Volsett, E.S., Hansen, S., 2004, “Colorectal cancer and MTHFR 677C>T and MTR 2756A>G polymorphisms”, Cancer, Epidemiology, Biomarkers and Prevention, 13:12, 2175-80.
  • United States Preventive Services Task Force (USPSTF). Screening for obesity in adults: recommendations and rationale. Ann Intern Med 2003 Dec 2;139(11):930-2.
  • Utermann G. Apolipoprotein E polymorphism in health and disease. (1987) Am Heart J 113:433–40. • Valavanis IK, Mougiakakou SG, Grimaldi KA, Nikita KS. A multifactorial analysis of obesity as CVD risk factor: use of neural network based methods in a nutrigenetics context. BMC bioinformatics. 2010;11:453.
  • Valenti, L., Pulixi, E., Fracanzani, A.L., 2005, “TNF genotype affects TNF release, insulin sensitivity, and the severity of liver disease in HCV chronic hepatitis”, J Hepatol, 43, 944-50. • van Ommen B, Bouwman J, Dragsted LO, Drevon CA, Elliott R, de Groot P, et al. Challenges of molecular nutrition research 6: the nutritional phenotype database to store, share and evaluate nutritional systems biology studies. Genes Nutr. 2010;5(3):189-203.
  • van Ommen B, Cavallieri D, Roche HM, Klein UI, Daniel H. The challenges for molecular nutrition research 4: the “nutritional systems biology level”. Genes Nutr. 2008;3(3-4):107-13.
  • van Ommen B, El-Sohemy A, Hesketh J, Kaput J, Fenech M, Evelo CT, et al. The Micronutrient Genomics Project: a community-driven knowledge base for micronutrient research. Genes Nutr. 2010;5(4):285-96.
  • van Ommen B, Fairweather-Tait S, Freidig A, Kardinaal A, Scalbert A, Wopereis S. A network biology model of micronutrient related health. Brit J Nutr. 2008;99:S72-S80.
  • van Ommen B, Keijer J, Kleemann R, Elliott R, Drevon CA, McArdle H, et al. The challenges for molecular nutrition research 2: quantification of the nutritional phenotype. Genes Nutr. 2008;3(2):51-9. • van Ommen B. Biological Networks and Micronutrient Requirements. Ann Nutr Metab. 2009;55:56-. • van Ommen B. Nutritional Requirements Based on Genotype and Phenotype. J Nutrigenet Nutrige. 2008;1(4):188-.
  • van Ommen B. Personalized nutrition from a health perspective: Luxury or necessity? Genes Nutr. 2007;2(1):3- 4. • van Rossum CT, Hoebee B, Seidell JC, Bouchard C, van Baak MA, de Groot CP, Chagnon M, de Graaf C, and Saris WH. Genetic factors as predictors of weight gain in young adult Dutch men and women. Int J Obes Relat Metab Disord 26:517-528, 2002.
  • Van’t Hooft, FM., Lundahl, B., Ragogna, F., Karpe, F., Olivecrona, G., Hamsten, A. (2000). Functional characterization of 4 polymorphisms in promoter region of hepatic lipase gene. Arterioscler. Thromb.Vasc. Biol., 20(5): 1335-9.
  • Vanhees L, De Sutter J, GeladaS N, Doyle F, Prescott E, Cornelissen V, Kouidi E, Dugmore D, Vanuzzo D, Börjesson M, Doherty P; EACPR. Importance of characteristics and modalities of physical activity and exercise in defining the benefits to cardiovascular health within the general population: recommendations from the EACPR (Part I). Eur J Prev Cardiol. 2012 Aug;19(4):670-86.
  • Vargas, H.R., Vazquez, R.M.C., Tapia, R., 2004, “Glu298Asp Endothelial Nitric Oxide Synthase Polymorphism Is a Risk Factor for Erectile Dysfunction in the Mexican Mestizo Population”, J Androl, 25:5, 728-32.
  • Varmus H. Ten years on–the human genome and medicine. N Engl J Med. 2010;362(21):2028-9.
  • Vaughn JD, Bailey LB, Shelnutt KP, Dunwoody KM, Maneval DR, Davis SR, Quinlivan EP, Gregory JF 3rd, Theriaque DW, Kauwell GP. Methionine synthase reductase 66A->G polymorphism is associated with increased plasma homocysteine concentration when combined with the homozygous methylenetetrahydrofolate reductase 677C->T variant. J Nutr. 2004 Nov;134(11):2985-90.
  • Vavilin, V. A., O. B. Chasovnikova, et al. (2000) Genetic polymorphism in glutathione S-transferase M1 and T1 in children with bronchial asthma. Vopr Med Khim 46(4): 388-97.
  • Velazques, A., Fernandez-Mejia, C. (2004) Vitamin metabolizm, genetics and the environment. Simpoulos, A. P., Ordovas, J. M. (eds): Nutrigenetics and Nutrigenomics. World Rev Nutr Diet. Basel, Karger, vol 93, pp 164- 187.
  • Vendrell, J., Fernandez-Real, J. M., Gutierrez, C., Zamora, A., Simon, I., Bardaji, A., Ricart, W., and Richart, C. (2003). A polymorphism in the promoter of the tumor necrosis factor-alpha gene (-308) is associated withcoronary heart disease in type 2 diabetic patients. Atherosclerosis 167, 257-264.
  • Vendrell, J., Real, J.M.F., Gutierrez, J., 2003, “A polymorphism in the promoter of the TNF- gene (-308) is asoociated with coronary heart disease in type 2 diabetic patients”, Atherosclerosis, 167, 257-64.
  • Vickers, M. A., Green, F. R., Terry, C., Mayosi, B. M., Julier, C., Lathrop, M., Ratcliffe, P. J., Watkins, H. C., and Keavney, B. (2002). Genotype at a promoter polymorphism of the interleukin-6 gene is associated with baseline levels of plasma C-reactive protein. Cardiovasc Res 53, 1029-1034.
  • Videman, T., Gibbons, L. E., Battie, M. C., Maravilla, K., Vanninen, E., Leppavuori, J., Kaprio, J., and Peltonen, L. (2001). The relative roles of intragenic polymorphisms of the vitamin d receptor gene in lumbar spine degeneration and bone density. Spine 26, E7-E12.
  • Viitanen, L., Pihlajamaki, J., Halonen, P., Lehtonen, M., Kareinen, A., Lehto, S., and Laakso, M. (2001). Association of angiotensin converting enzyme and plasminogen activator inhibitor-1 promoter gene polymorphisms with features of the insulin resistance syndrome in patients with premature coronary heart disease.Atherosclerosis 157, 57-64.
  • Vijg J. Somatic mutations and aging: a re-evaluation. Mutat Res. 2000 Jan 17;447(1):117-35.
  • Vineis, P., Veglia, F., Anttila, S., 2004, “CYP1A1, GSTM1 and GSTT1 polymorphisms and lung cancer: a pooled analysis of gene-/gene interactions”, Biomarkers, 9:3, 298-305.
  • Visvikis, S.S., Marteau, J.B., 2006, “Genetic variants predisposing to cardiovascular disease”, Curr Opi Lipidol, 17, 139-151.
  • von Zglinicki T. Oxidative stress shortens telomeres. Trends Biochem Sci. 2002 Jul;27(7):339-44.
  • Vozarova, B., Knovler, J.M., Gallart, L., 2003, “The interleukin 6 (-174) G/Cpromoter polymorphism is associated with type-2 diabetes mellitus in native Americans and Caucasians”, Hum Genet, 112, 409-413
  • Wadelius M, Chen LY, Eriksson N, Bumpstead S, Ghori J, Wadelius C, Bentley D, McGinnis R, Deloukas P. Association of warfarin dose with genes involved in its action and metabolism.Hum Genet. 2006 Oct 18.
  • Wald, D. S., Law, M., and Morris, J. K. (2002). Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. Bmj 325, 1202.
  • Walford, RL. The Immunologic theory of aging. Munksgaard, Copenhagen; 1969.
  • Wallstrom, P., Frenkel, K., Wirfalt, E., Gullberg, B., Karkoszka, J., Seidegard, J., Janzon, L., and Berglund, G. (2003). Antibodies against 5-hydroxymethyl-2′-deoxyuridine are associated with lifestyle factors and GSTM1 genotype: a report from the Malmo Diet and Cancer cohort. Cancer Epidemiol Biomarkers Prev 12, 444-451.
  • Wang D, Liu R, Zhu H, Zhou D, Mei Q, Xu G. Vitamin D receptor Fok I polymorphism is associated with low bone mineral density in postmenopausal women: a meta-analysis focused on populations in Asian countries. Eur J Obstet Gynecol Reprod Biol. 2013 Jul;169(2):380-6.
  • Wang JL, Wang HG, Gao HQ, Zhai GX, Chang P, Chen YG. Endothelial nitric oxide synthase polymorphisms and erectile dysfunction: a meta-analysis. J Sex Med. 2010 Dec;7(12):3889-98.
  • Wang S, Wang F, Shi X, Dai J, Peng Y, Guo X, Wang X, Shen H, Hu Z. Association between manganese superoxide dismutase (MnSOD) Val-9Ala polymorphism and cancer risk – A meta-analysis. Eur J Cancer. 2009 Nov;45(16):2874-81.
  • Weisberg, I. S., Jacques, P. F., Selhub, J., Bostom, A. G., Chen, Z., Curtis Ellison, R., Eckfeldt, J. H., and Rozen, R.(2001). The 1298A–>C polymorphism in ethylenetetrahydrofolate reductase (MTHFR): in vitro expression and association with homocysteine. Atherosclerosis 156, 409-415.
  • Weismann A. Uber die Dauer Das Lebens. 1882. Jena, içinde: Bell G. Evolutionary and Nonevolutionary Theories of Senescence. Am. Nat. 1984 Vol 124. Pp.600-603.
  • Weiss EP, Kulaputana O, Ghiu IA, Brandauer J, Wohn CR, Phares DA, Shuldiner AR, and Hagberg JM. Endurance training-induced changes in the insulin response to oral glucose are associated with the peroxisome proliferator-activated receptor-gamma2 Pro12Ala genotype in men but not in women. Metabolism 54: 97-102, 2005.
  • Welker GC, Lookinland S, Tiedeman ME, Beckstrand RL., 2004, “The role of genetics in the risk of thromboembolism: prothrombin 20210A and oral contraceptive therapy”, J Am Acad Nurse Pract, 16(3):106-15, 138.
  • Wernimont SM, Clark AG, Stover PJ, Wells MT, Litonjua AA, Weiss ST, et al. Folate Network Genetic Variation Predicts Cardiovascular Disease Risk in Non-Hispanic White Males. The Journal of Nutrition. 2012.
  • Weston AD, Hood L. Systems biology, proteomics, and the future of health care: toward predictive, preventative, and personalized medicine. J Proteome Res. 2004;3(2):179-96.
  • Westphal, G.A., Schnuch, A., Mossner, R., 2003, “Cytokine gene polymorphisms in allergic contact dermatitis”, Contact Dermatitis, 48, 93-98.
  • White MA, Martin PD, Newton RL, Walden HM, York-Crowe EE, Gordon ST, Ryan DH, Williamson DA. Mediators of weight loss in a family-based intervention presented over the Internet. Obes Res. 2004;12:1050 – 1059. •
    WHO – World Health Organization (2002). World Health Report 2002 – Reducing Risks, Promoting Healthy Life. Geneva, 2002.
  • WHO – World Health Organization (2003). World Health Report 2003 – shaping the future. Geneva, 2003. • WHO – World Health Organization (2005). Global Programming Note 2005-2007: Diet and Physical Activity.
  • WHO – World Health Organization (Kasım 2002). Globalization, Diets and Noncommunicable Diseases.
  • WHO Diabetes Programme – World Health Organization Diabetes Programme (2005). Prevalance of diabetes worldwide.
  • WHO Euro – World Health Organization European Regional Office (1999). Health 21: The health for all policy framework for the WHO European Region. European Health for All Series, No. 6, Copenhagen, pp 54-55.
  • WHO/FAO – World Health Organization/Food and Agriculture Organization (2003). Diet, Nutrition and the Prevention of Chronic Diseases – Report of a Joint WHO/FAO Expert Consultation. Technical Report Series No:916, Geneva.
  • WHO/NMH – World Health Organization, Noncommunicable Diseases and Mental Health (2003). Health and Development Through Physical Activity and Sport. WHO/NMH/NPH/PAH/ 03.2, WHO, 2003.
  • Wiemels, J. L., Smith, R. N., Taylor, G. M., Eden, O. B., Alexander, F. E., and Greaves, M. F. (2001).Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia. Proc Natl Acad Sci U S A 98, 4004-4009. •
    Wilkinson, R. J., Llewelyn, M., Toossi, Z., Patel, P., Pasvol, G., Lalvani, A., Wright, D., Latif, M., and Davidson, R. N.(2000). Influence of vitamin D deficiency and vitamin D receptor polymorphisms on tuberculosis among Gujarati Asians in west London: a case-control study. Lancet 355, 618-621.
  • Williams CM, Ordovas JM, Lairon D, Hesketh J, Lietz G, Gibney M, et al. The challenges for molecular nutrition research 1: linking genotype to healthy nutrition. Genes Nutr. 2008;3(2):41-9.
  • Williams GC. Pleiotropy, natural selection, and the evolution of senescence. Evol. 1957. 11: 398-411. • Wilson, M. H., P. J. Grant, et al. (2000) Glutathione S-transferase M1 null genotype is associated with a decreased risk of myocardial infarction. Faseb J 14(5): 791-6.
  • Witte, J. S., Palmer, L. J., O’Connor, R. D., Hopkins, P. J., and Hall, J. M. (2002). Relation between tumour necrosis factor polymorphism TNFalpha-308 and risk of asthma. Eur J Hum Genet 10, 82-85. • Wolf AM, Wender RC, Etzioni RB, Thompson IM, D’Amico AV, Volk RJ, Brooks DD, Dash C, Guessous I, Andrews K, DeSantis C, Smith RA, American Cancer Society Prostate Cancer Advisory Committee. American Cancer Society guideline for the early detection of prostate cancer: update 2010. CA Cancer J Clin 2010 Mar- Apr;60(2):70-98.
  • Wolff, B., Braun, C., Schluter, C., 2005, “Endothelial nitric oxide synthase Glu298 Asp polymorphism, carotid atherosclerosis and intima-media thickness in a general population sample”, Clin Sci, 109, 475-81.
  • Wolford, J.K., Colligan, P.B., Gruber, J.D., 2003, “Variants in the IL-6 receptor gene are associated with obesity in Pima Indians”, Mol Genet Metabol, 80, 338-43.
  • Woods, A., Brull, D. J., Humpries, S. E., Montgomery, H. E. (2000). Genetics of inflamation and risk of coronary artery disease: The central role of interleukin-6. EurHeart J 200;21:1574-1583.
  • Woodside JV, McCall D, McGartland C, Young IS. Micronutrients: dietary intake v. supplement use. P Nutr Soc. 2005;64(4):543-53.
  • Woodson, K., Tangrea, J.A., Lehman, T.A., 2003, “MnSOD polymorphism , -tocopherol supplementation and prostate cancer risk in the alpha-tocopherol, beta-carotene cancer prevention study “, Cancer Causes and Control, 14, 513-8.
  • World Health Organization. Obesity: Preventing and Managing the Global Epidemic. Technical Report Series no. 894. WHO, Geneva, 2000.
  • World Health Organization. The World Health Report 2002. Reducing Risks, Promoting Healthy Life. IOTF research for the WHO Global Burden of Disease programme.
  • Wramsby, M.L., Linder, M.S., Bremme, K., 2000, “Primary habitual abortions are associated with high frequency of Factor V Leiden mutation”, Fertility and Sterility, 74:5, 987-91.
  • Wright C, Burton H, Hall A, Moorthie S, Pokorska-Bocci A, Sagoo G, et al. Next steps in the sequence. The implications of whole genome sequencing for health in the UK. Cambridge: PHG Foundation; 2011 October 2011.
  • Wright WE, Shay JW. Telomere biology in aging and cancer. J Am Geriatr Soc. 2005 Sep;53(9 Suppl):S292-4.
  • Wrone, E. M., Zehnder, J. L., Hornberger, J. M., McCann, L. M., Coplon, N. S., and Fortmann, S. P. (2001). An MTHFR variant, homocysteine, and cardiovascular comorbidity in renal disease. Kidney Int 60, 1106-1113.
  • Wu K, Wang X, Xie Z, Liu Z, Lu Y. Glutathione S-transferase P1 gene polymorphism and bladder cancer susceptibility: an updated analysis. Mol Biol Rep. 2013 Jan;40(1):687-95.
  • Wu, D., X. Wang, et al. (2000) Metabolic gene polymorphisms and risk of dysmenorrhea. Epidemiology 11(6): 648-53. • Wu, O., Robertson, L., Langhorne, P., Twaddle, S., Lowe, G.D., Clark, P., Greaves, M., Walker, I.D., Brenkel, I., Regan, L., Greer, I.A., 2005, “Oral contraceptives, hormone replacement therapy, thrombophilias and risk of venous thromboembolism: a systematic review. The Thrombosis: Risk and Economic Assessment of Thrombophilia Screening (TREATS) Study.”, Thromb Haemost, 94(1):17-25.
  • Wybranska, I., Malczewska-Malec, M., Niedbal, S., Naskalski, J. W., and Dembinska-Kiec, A. (2003). The TNFalpha gene NcoI polymorphism at position -308 of the promoter influences insulin resistance, and increasesserum triglycerides after postprandial lipaemia in familiar obesity. Clin Chem Lab Med 41, 501-510.
  • Xinli W, Xiaomei T, Meihua P, Song L. Association of a mutation in the beta3-adrenergic receptor gene with obesity and response to dietary intervention in Chinese children. Acta Paediatr. 2001 Nov;90(11):1233-7.
  • Xiong, P.; Bondy, M. L, et al. (2001) Sensitivity to benzo(a)pyrene diol-epoxide associated with risk of breast cancer in young women and modulation by glutathione S-transferase polymorphisms: a case-control study. Cancer Research 61(23): 8465-9.
  • Xu B, Tong N, Li JM, Zhang ZD, Wu HF. ELAC2 polymorphisms and prostate cancer risk: a meta-analysis based on 18 case-control studies. Prostate Cancer Prostatic Dis. 2010 Sep;13(3):270-7.
  • Xue, K., L. Xu, et al. (2001) Polymorphisms of the CYP1A1 and GSTM1 genes and their combined effects on individual susceptibility to lung cancer in a Chinese population. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 18(2): 125-7.
  • Yamada Y, Ichihara S, Nishida T. Proinflammatory gene polymorphisms and ischemic stroke. Curr Pharm Des. 2008;14(33):3590-600.
  • Yamada, Y., Ando, F., Niino, N., 2005, “Association of a -1997G–>T polymorphism of the collagen Ialpha1 gene with bone mineral density in postmenopausal Japanese women”, Hum Biol, 77:1, 27-36.
  • Yang B, Fan S, Zhi X, et al. Associations of MTHFR Gene Polymorphisms with Hypertension and Hypertension in Pregnancy: A Meta-Analysis from 114 Studies with 15411 Cases and 21970 Controls. PLoS One. 2014 Feb 5;9(2):e87497. doi: 10.1371/journal.pone.0087497.
  • Yang, W., Kelly, T. and He, J. Genetic Epidemiology of Obesity. Epidem. Rev. (2007) 29: 49-61.
  • Yang, Y., Narvaez, E.R., Niu, T., 2004, “Genetic variants of the lipoprotein lipase gene and myocardial infarction in the Central Valley of Costa Rica”, J Lipid Res, 45, 2106-9.
  • Ye, Z., Liu, E.H.C., Higgins, J.P.T., 2006, “Seven haemostatic gene polymorphisms in coronary disease:meta-analysis of 66 155 cases and 91 307 controls”, Lancet, 367, 651-8.
  • Yea, S. S., Yang, Y. I., Jang, W. H., Lee, Y. J., Bae, H. S., and Paik, K. H. (2001). Association between TNF-alpha promoter polymorphism and Helicobacter pylori cagA subtype infection. J Clin Pathol 54, 703-706.
  •  Yilmaz, H., Isbir, T., Agachan, B., 2005, “Effects of cholesterol ester transfer protein Taq1B gene polymorphism on serum lipoprotein levels in Turkish coronary artery disease patients”, Cell Biochem Funct, 23, 23-28.
  • Yilmaz, H., Isbir, T., Karaali, Z.E., 2004, “Taq1B polymorphism of CETP gene on lipid abnormalities in patients with type II diabetes mellitus”, Int J Mol Med, 13:6, 889-93.
  • Yingdong, Z., Zhigang, Z., Yang, L., 2002, “Association of plasma homocysteine level and N5,N10- methylenetetrahydrofolate reductase gene polymorphism with cerebral infarction”, Chin Med Sci J, 17:4, 231- 235.
  • Yoo, J.H., 2005, “Deletion polymorphism in the gene for angiotensin-converting enzyme is associated with essential hypertension in men born during the Pacific War”, Mec Ageing Develop, 126, 899-905.
  • Yoshimura T, Yoshimura M, Tabata A, Shimasaki Y, Nakayama M, Miyamoto Y, Saito Y, Nakao K, Yasue H, Okamura H. Association of the missense Glu298Asp variant of the endothelial nitric oxide synthase gene with severe preeclampsia. J Soc Gynecol Investig. 2000 Jul-Aug;7(4):238-41.
  • Yun, B.R., El-Sohemi, A., Cornelis, M.C., 2005, “Glutathione S-transferase M1, T1, and P1 genotypes and rheumatoid arthritis”, J Rheumatol, 32:6, 992-7.
  • Zajickova, K., Zofkova, I., Bahbouh, R., 2002, “Vitamin D Receptor Gene Polymorphisms, Bone Mineral Density and Bone Turnover: FokI Genotype is Related to Postmenopausal Bone Mass”, Physiol Res, 51, 501-9.
  • Zambon A, Deeb SS, Pauletto P, Crepaldi G, Brunzell JD. (2003) Hepatic lipase: a marker for cardiovascular disease risk and response to therapy. Curr Opin Lipidol. 14(2):179-89.
  • Zhang, Z., Shi, Q., Liu, Z., 2005, “Polymorphisms of methionine synthase and methionine synthase reductase and risk of squamous cell carcinoma of the head and neck: a case-control analysis”, Canc Epidemiol Biomarkers Prev, 14:5, 1188-93.
  • Zhao, B., A. Seow, et al. (2001) Dietary Isothiocyanates, Glutathione S-transferase -M1, -T1 Polymorphisms and Lung Cancer Risk among Chinese Women in Singapore. Cancer Epidemiol Biomarkers Prev 10(10):1063- 7.
  • Zhao, S.P., Tong, Q.G., Xiao, Z.J., 2003, “The lipoprotein lipase Ser447Ter mutation and risk of stroke in the Chinese”, Clin Chim Acta, 330, 161-4.
  • Zheng, W., Wen, W.Q., Gustafson, D.R., 2002, “GSTM1 and GSTT1 polymorphisms and postmenopausal breast cancer risk”, Breast Canc Res Treatment, 74, 9-16. • Zhu, H., Wicker, N.J., Shaw, G.M., 2003, “Homocysteine remethylation enzyme polymorphisms and increased risks for neural tube defects”, Mol Genet Metab, 78, 216-21.
  • Zhua H, W. N., Shawb G, Lammerc E, Hendricksd K, Suarezd L, Canfieldd M and Finnell R (2003).Homocysteine remethylation enzyme polymorphisms and increased risks for neural tube defects. Molecular Genetics and Metabolism, Mol Genet Metab.;78(3):216-21.
  • Zimmern RL, Brice PC. Realizing the potential of genomics: Translation is not translational research. Genet Med. 2009;11(12):898-9.
  • Zimmern RL, Khoury MJ. The impact of genomics on public health practice: the case for change. Public Health Genomics. 2012;15(3-4):118-24.
  • Zimmern RL. Genomics and individuals in public health practice: are we luddites or can we meet the challenge? J Public Health (Oxf). 2011;33(4):477-82.
  • Zmuda, J. M., Cauley, J. A., and Ferrell, R. E. (2000). Molecular epidemiology of vitamin D receptor gene variants. Epidemiol Rev 22, 203-217.
  • Zusterzeel, P. L., W. L. Nelen, et al. (2000) Polymorphisms in biotransformation enzymes and the risk for recurrent early pregnancy loss. Mol Hum Reprod 6(5): 474-8.